unit 4 vaccines

Question 1

composition of killed/inactivated vaccines

Answer 1

killed/inactivated

Question 2

use/effectiveness of killed/inactivated

Answer 2

lose virulence and instead provides immune response
–> flu shot, rabies

Question 3

composition of live-attenuated vaccines

Answer 3

contain alive mutant form of pathogen that grows poorly in humans (or are no longer pathogenic)

Question 4

use/effectiveness of live attenuated vaccines

Answer 4

provides best protective immunity as it matches natural infection (enough to stimulate response but not cause an infection)
–> MMR, chickenpox

Question 5

composition of subunit

Answer 5

purified single of mixed components (proteins/polyssacharides)
–> these components are the more immunogenic part that will stimulate strongest immune reaction

Question 6

use/effectiveness of subunit

Answer 6

toxoid (tetanus)
–> antibodies produced against all components

Question 7

composition of conjugate vaccine

Answer 7

protein-polysaccharide complex
–> on their own polysaccharides cannot active T helper cells so they need complex

Question 8

use/effectiveness of conjugate vaccines

Answer 8

when linked stimulates T cell activation and results in immunologic memory
–> meningococcal and Prevnar 13