unit 10

Question 1

examples of slow virus diseases

Answer 1

SSPE –> measles (mutated m gene)

PRP –> rubella (congenital rubella)

Cancer –> HTLV-1

Question 2

what is a slow virus disease

Answer 2

virus that has a prolonged incubation period in which it is slowly replicating without being detected
–> it will then gradually damage cells

Question 3

prions

Answer 3

misfolded proteins that transmit their infectiousness to others

Question 4

PrPc

Answer 4

normal protein isoform

Question 5

PrPsc

Answer 5

infectious isoform

Question 6

theory explaining the mode of replication of prions

Answer 6

infectious form binds to normal form and converts it through binding

Question 7

how are prions typically transmitted

Answer 7

either acquired (GI tract/broken skin or contaminated surgical instruments)

inherited (passed down)

sporadic (mutations)

Question 8

pathogenesis of the transmissible spongiform encephalopathies

Answer 8

PrPsc moves form PNS to CNS
and when it increases it will lead to amyloid formation and cause holes where neurons die

Question 9

match the TSE with its natural host

Answer 9

scrapie –> goat/sheep
BSE –> cattle
CWD –> deer
Kuru –> humans
CJD/vCJD –> humans and cattle

Question 10

symptoms and time of course of CJD and variant vCJD

Answer 10

sensory disturbances, memory loss, progressive dementia, spasms
–> main difference is that vCJD has earlier onset age and longer course

Question 11

origin of vCJD

Answer 11

BSE (eating infected cattle)

Question 12

laboratory tests used to diagnose CJD

Answer 12

serology (14-3-3 protein presence)

perfrom RT-Quic which test ability of sample to convert recombinant protein