unit 7 Flashcards
Define metabolism
Set of life-sustaining chemical transformations within the cells of living organisms
Transformations of energy substrates are biased towards ____ / _____ or _____ / _____
Storage/anabolism
Breakdown/catabolism
Regulation of metabolism can be _____ or _____
Endocrine
neural
Ingested biomolecules three possible fates
Fuel
Build
Store
The three types of nutrients that are immediately able to be used (because they are circulating in the plasma)
Glucose
Free fatty acids
Amino acids
The fed/absorptive state of metabolism focuses on _____, products of digestion being ____ and used for ______
Anabolic
Absorbed
Synthesis or are stored
The fasted/postabsorptive state of metabolism focuses on ______, the energy will come from ______
Catabolism
Body stores
In fed state metabolism under influence of ____, enzyme activity for forward reaction increases. Enzyme for ______ breakdown are inhibited.
Insulin
Glycogen
In fasted state metabolism under influence of ____, enzymes that break down _____ are more active. Enzymes for _____ synthesis are inhibited.
Glucagon
Glycogen
Glycogen
Fasted state go through ______ to create glucose-6-phosphate
Gluconeogenesis
Carbs are stored as glycogen in the ___ which can be broken down and exported as free glucose
Liver
Carbs are stored as glycogen in the ___ which can NOT be broken down and exported as free glucose
Muscle
Glycogen in the muscles are used ______ or exported as _______ to the liver to enter the ________ pathway
Within the muscles
Pyruvate/lactate
Gluconeogenesis
Triglycerides in ________ is exported as glycerol into the ____ to enter the _______ pathway
Adipose
Liver
Gluconeogenesis
Fats within the ________ is exported as _______ and undergo ___________
Adipose
Fatty acids
Beta oxidation
If ______ proceeds faster then acetyl CoA can be used in ____, ketone bodies are formed
Lipolysis
TCA cycle
Ketone bodies enter the blood and serve as energy for _______
The brain
Why are ketone bodies potentially dangerous?
They can disrupt the acid base balance in the body, acid base balance
The glucostatic theory of eating
Intake is regulated by glucose levels monitored by centers in the hypothalamus
The lipostatic theory
Signals from fat stores to brain modulate eating behaviours
Leptin was discovered in 1994. It is a _____ ______ synthesized in _________ tissue
Protein hormone
adipose
A mutation was identified in mice that caused over eating called the _____ gene
Ob
The mutation of leptin receptors discovered in mice was called the _____ gene
Db
Cells of empty stomach secrete _____ which causes an _____ in appetite
Ghrelin
Increase
When the stomach is stretched there is a _________ in acid which innervates acid sensing ion channels
Increase
In response to fat or protein in the lumen of the small intestine there is an increase in _____
CCK
To decrease appetite the lower small intestine has increased concentrations of ______ and _____ which inhibits the release of _________. Both of these are triggered by _________ in the lumen and a _______ from the upper small intestine
GLP-1
Peptide yy
Neuropeptide y
Macronurtients
Neural reflex
Neuropeptide y is a __________ in the ________ of appetite
Neurotransmitter
stimulation
Alpha cells secrete ______, d cells secrete _______, beta cells secrete _______
Glucagon
Somatostatin
insulin
______ transporters move glucose into ______ cells by facilitated diffusion
GLUT2
Beta
ATP causes potassium leak channels on beta cells to _____
Close
When blood glucose is high glucose will enter the cell and go through _______ and the _________ to create ATP
Glycolysis
Citric acid cycle
When the beta cells have high concentrations of ATP the __________ will close and cause the ________ to become depolarized and ____ will enter the cell to push ____ to exocytosis
Potassium leak channels
Calcium channels
Calcium
insulin
In the fed state, high insulin causes….
Glucose oxidation
Glycogen synthesis
Fat synthesis
Protein synthesis
(GO GyS FP)
In the fasted state, high levels of glucagon cause…
Glycogenolysis
Gluconeogenesis
Ketogenesis
Insulin is released when these 5 things increase
Plasma glucose
Plasma amino acids
GLP-1
GIP
Parasympathetic activity
The three targets of insulin
Striated muscle
Adipose
Liver