UNIT 3 Flashcards
● Small, naked viruses
● Positive sense Single stranded RNA virus
Picornaviridae
Genus causing infection to man:
○ Enterovirus– enteric tract; Largest
○ Hepatovirus– liver
○ Parechovirus
○ Kobuvirus
Picorna
One of the most important because it is one of the
largest by number of members.
Picorna
has more than 280 members, so it has to be
grouped by genus.
Picorna
Causes Poliomyelitis(Polio)
● Transmission: Oral-fecal route
Poliovirus
Affects motor neurons that are myelinated
Poliomyelitis
Replicates in the oropharynx and intestinal tract
Polio
It is Irreparable once motor neurons are
damaged
Polio
Paano siya nakapunta sa spinal cord?
Hematogenous route
Oral-fecal → blood → motor neurons of
spinal cord.
TRUE
Only enterovirus with vaccine.
Polio
major disease stages of polio
Mild
Aseptic meningitis
Paralytic
Progressive postpoliomyelitis muscle atrophy
a. Sequelae of Paralytic.
b. There is still some sort of control
from the waist down(Lower
extremities).
c. Damaged motor neurons
Progressive Postpoliomyelitis Muscle
Atrophy
Would only last a few days.
Mild
BIPHASIC - First stage of fever that
would last 2-3 days, then gagaling
ka ksi no symptoms for 3-4 days
then biglang boom magkakalagnat
ka uli and mas malala na siya ksi
may kasama nang stiff neck.
Aseptic meningitis
● Second most common enterovirus
Coxsackie virus
Transmission: Oral-fecal, respiratory aerosols
Coxsackie virus
Herpangina
A16
Group a coxsackie virus
Mostly located in the mouth(Hard
and Soft Palate)
Herpangina
Most of the cases are kids or
toddlers
■ Caused by A5, A10, A16
A16
Pleurodynia or Bornholm disease
Myocarditis
Pericarditis
Group b
Has sharp stabbing pain in the
chest.
■ Treatment: Supportive
Pleurodynia
Bornholm
Leading cause of aseptic meningitis
Echovirus
Lab dx: Cell culture(Serological test not useful)
Echovirus
_________-(Additional info) but eto tawag pag
flinex yung neck tas nagjerk yung knees.
○ If positive for this, most likely it is ____
Brudzinki’s Sign
meningitis
Infect nose and throat
● Agent of common colds
● Acid labile
● Grow better at 33°C
● Transmission: contact with contaminated hands
● More than 150 members !
human rhinovirus a,b,c
Can cause secondary bacterial infection
human rhinovirus a,b,c