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DNA VIRUSES MYCOVIRO LEC Flashcards

1
Q

Double stranded DNA
● With single stranded region
● Causes diseases related to liver
● can cause cancer (Hepatocarcinoma)

A

HEPADNAVIRIDAE

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2
Q

Genus: Orthohepadnavirus
● causes Hepatitis B

A

HEPATITIS B VIRUS

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3
Q

With DANE particle siya lang may ganto

A

HEPA B

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4
Q

– surface antigen –outer membrane for
screening

A

HBsAg

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5
Q

core antigen – surrounds the DNA

A

HBcAg

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6
Q

– components of the core antigen
(envelope antigens)

A

HBeAg

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7
Q

Sexual contact
● Blood transfusion
● Inoculation of contaminated secretions

A

HEPADNA

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8
Q

present in acute & chronic infection

A

HBsAg

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9
Q

indicates recovery or immunity

A

Anti-HBS

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10
Q

present in acute (<6 months) infectio

A

Anti-HBc IgM

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11
Q

previous or ongoing infection

A

Anti-HBc–

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12
Q

HBeAg– virus is replicating/ high levels
Anti-HBe– indicates lower level of HBV

A

TRUE

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13
Q

Double stranded DNA
● Causes lytic infection and latent infection
● Remain in WBC & peripheral nerves

A

HERPESVIRIDAE

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14
Q

Simplexvirus

Oral Herpes– Gingivostomatitis
HSV Encephalitis (adult)
Ocular Herpes– Keratoconjunctivitis

A

HSV 1

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15
Q

Treatment: Acyclovir

Transmission: Salivary (Oral)

A

HSV 1

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16
Q

Genital Herpes
○ Neonatal Herpes
○ HSV Encephalitis (neonates)

A

HSV 2

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17
Q

Contact with contaminated secretions
● Skin to skin contact
● Transmission between discordant partners

A

HERPES SIMPLEX 2

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18
Q

Electron Microscope
● PCR
● Pap’s Smear
● Dark Fluorescence Microscopy
● Indirect Fluorescence
● Culture

A

HERPES V 2

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19
Q

Varicellovirus

Chickenpox- auto Varicella Zoster ang tawag
Shingles (recurrent form) - Herpes Zoster

A

VZV OR HHV3

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20
Q

Droplet inhalation or respiratory droplets
● Direct contact with infectious lesions

A

VZV OR HHV3

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21
Q

Tzanck Smear
○ vesicles are used
○ multinucleated giant cells are seen in
microscopy
○ can be seen in regular microscope

A

VZV OR HHV 3

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22
Q

Genus: Lymphocryptovirus
● causes: Infectious Mononucleosis (Kissing disease)
● Produce tumors
● Associated with Burkitt’s Lymphoma and other B-cell Lymphoma

A

EBV OR HHV4

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23
Q

Hematology – differential smear

Immunology:
○ Heterophil Antibody test
○ Monospot test
○ EBV Specific Antibody test

A

EBV OR HHV 4

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24
Q

Viral capsid antigen

A

ANTI VCA

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25
Early antigen ○ can persist up until 6 months
Anti-EA IgG
26
○ diffused ○ disappear after 6 minths
Anti-EA/D
27
○ restricted ○ persists up until 2 years
Anti-EA/R
28
EBV nuclear antigen
ANTI- EBNA
29
Genus: Cytomegalovirus ● Formerly “Salivary gland” virus ○ Salivary Gland Cancer
CMV OR HHV 5
30
Cytomegalic inclusion disease Pneumonia (in immunosuppressed pts) Similar to mononucleosis Remain latent in WBC, endothelial organs
CMV O HHV5
31
Sexual contact ● Transplacental ● Blood transfusion
CMV OR HHV5
32
Microscopy – ● Shell vial culture ● Serologic tests ● PCR “Owl’s eyes” appearance
CMV OR HHV 5
33
Genus: Roseolovirus causes ○ Exanthem subitum or Roseola infantum or 6th disease INFECT T CELLS
HHV6
34
Inhalation Respiratory droplets PCR Isolated thru T-cell culture
HHV6
35
Genus: Rhadinovirus ○ common in AIDS patients
HHV 8
36
causes ○ Kaposi sarcoma in the Thoracic Cavity ● Transmission: Sexual contact ● Diagnosis: PCR ● Cannot be recovered in cell culture
HHV 8
37
Double stranded DNA ● Replicate in cytoplasm
POXVIRIDAE
38
Largest and most complex of all virus ● Brick or ovoid shape ● Produces skin lesions
POXVIRIDAE
39
Genus: Orthopoxvirus ● Causes: Smallpox ● First virus to be eradicated Transmission: Inhalation of respiratory droplets, Saliva
VARIOLA OR SMALLPOX
40
Genus: Orthopoxvirus ● Non-pathogenic to man ● Used in the development of smallpox vaccine
VACCINIA
41
Genus: Molluscipoxvirus ● Cause: small pink warts (benign tumors in skin);
MOLLUSCUM CONTAGIOSUM VIRUS
42
Transmission: Direct contact, use of contaminated fomites ● Diagnosis: Excisional biopsy, PCR
MOLLUSCUM CONTAGIOSUM VIRUS
43
Genus: Orthopoxvirus ● Zoonotic infection (cows) ○ when farmers milk cows, they can get this infection ● Transmission: Touching udder of infected cow (animal to man)
COWPOX
44
Orthopoxvirus ● Zoonotic infection (monkeys, rodents) Transmission: Direct inoculation, contact with contaminated blood Gambian rats
MONKEYPOX
45
Diagnosis: PCR ○ Signs & Symptoms: Lymphadenopathy in the axillary area Treatment: supportive ○ Lesions appear in 2-3 weeks(14-21 days) isolation period
MONKEYPOX
46
VARIOLA OR SMALL POX VACCINIA COWPOX MONKEY POX
ORTHOPOXVIRUS
47
Genus: Parapoxvirus ● Zoonotic infection (goats, sheep) ○ occupational disease of sheep farmers ● arms, forearms, fingers
ORF VIRUS
48
Causes: Orf or contagiosum pustular dermatitis Transmission: Direct inoculation or contact with contaminated equipment in broken skin
ORF VIRUS
49
Single stranded linear DNA ● Very small naked virus ● smallest DNA virus on Earth
PARVOVIRIDAE
50
DEFECTIVE NON-DEFECTIVE
PARVOVIRIDAE
51
Genus: Erythrovirus Causes: Erythema infectiosum (5th disease) slapped cheek appearance ● Transmission: Respiratory droplets, blood borne ● Diagnosis: PCR
B19
52
Genus: Bocavirus Causes: variety of upper and lower respiratory tract illness ● common in children (wheezing sound) ● Transmission: Respiratory droplets ● Diagnosis: PCR
HBoV
53
Double stranded DNA ● Causes warts and condylomas in man ● one of the 7 cancer viruses ● 150 serotypes ● Viral cause of tumor in man
PAPILLO
54
Causes: Condyloma acuminate
HPV
55
40- sexually transmitted ● Most common STD ● Transmission: Sexual contact, skin to skin ● Diagnosis: Pap’s smea
HPV
56
PLANTAR AND WARTS
HPV1
57
2 and 4: Skin
HPV 2 AND 4
58
Anogenital (Anal Cancer)
HPV 6
59
16 and 18 Genital: Cervical Cancer
HPV 16 and 18
60
Double stranded DNA 14 species are known to infect humans ● very common and typically asymptomatic in most human populations studied ○ also a cancer virus
POLYO
61
Kidneys of transplant patients First isolated in urine of immunosuppressed kidney tissue transplant patient
POLYOMA V 1 BK VIRUS
62
In encephalopathy ○ Can cause brain tumors First isolated from patient with progressive multifocal encephalopathy ○ can cause brain tumours ● John Cunningham ● Causes disease in AIDS patients
HUMAN POLYO 2 JC VIRUS
63
Isolated in the nasopharyngeal secretions (usually in kids) Discovered in 2007 in samples of human respiratory secretions Named after Karolinska Institute (site of collection)
HUMAN POLYO 3 KI VIRUS
64
Discovered in 2007 in samples of human respiratory secretions ● Named after Washington University ○ Isolated in nasopharyngeal secretions ○ Persist in kidney and lymphoid tissues
HUMAN POLYO 4 WU VIRUS
65
Genus: Orthopolyomavirus ● Cause: Merkel cell cancer (a form of skin cancer) ● one of the seven human oncoviruses
MERKELL CELL VIRUS
66
HUMAN POLYO 8
Trichodysplasia Spinulosa virus(8)
67
HUMAN POLYO 10
MW VIRUS MALAWI
68
HUMAN POLYO 11
STL VIRUS (11)- ST LOUIS
69
Now Jersey virus (13)
HUMAN POLYO 13
70
Double stranded linear DNA ● 51 serotypes ● Replicate in nucleus
ADENOVIRIDAE
71
Genus: Mastadenovirus ● cause of common cold ● Cause: upper respiratory diseases ○ Pharyngitis ○ Conjunctivitis ○ pneumonia ● Causes cancer in animals ○ Ex. Rodents
ADENOVIRUS
72
Single stranded DNA positive sense ● Newly discovered genus ● Anello – RING (circular genome)
ANELLOVIRIDAE
73
Genus: Alphatorquevirus ● Reported in Japanese patient in 1997 ● Extremely common even in healthy individuals ● Transmission: Blood transfusion, sexual contact, saliva droplets ○ Hepatitis of unknown cause
TTV OR TORQUE TENO VIRUS
74
Genus: Alphatorquevirus ● Reported in Japanese patient in 1997 ● Extremely common even in healthy individuals ● Transmission: Blood transfusion, sexual contact, saliva droplets ○ Hepatitis of unknown cause
TTV OR TORQUE TENO VIRUS
75
SINGLE STRANDED
ANELLO PARVO

MYCOVIRO (10 decks)

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