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FHB Mikayla > Unit 2 L7 Gas Transport > Flashcards

Unit 2 L7 Gas Transport Flashcards

1
Q

O2 is carried in the blood in 2 forms

A

Dissolved

Bound to hemoglobin

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2
Q

PAO2 defintion

A

Alveolar partial pressure of oxygen

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3
Q

PaO2 defintiion

A

Arterial partial pressure of oxygen (dissolved)

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4
Q

SaO2 definition

A

Oxygehmoglobin or hemoglobin saturation, so the percentage of hemoglobin sites with oxygen bound. This is dictated by PaO2 and PvO2

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5
Q

CaO2 definition

A

Oxygen content, oxygen concentration. Total oxygen in the blood per unit volume, aka dissolved oxygen + oxyhemoglobin

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6
Q

How can we go from PAO2 to total oxygen in the blood?

A

PAO2 gives us PaO2, which gives us SaO2, which gives us CaO2. In other words, PO2 –> [O2] dissolved –> O2-Hb% –> total oxygen in blood

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7
Q

The amount of dissolved oxygen in the blood dictates ______

A

How much oxygen is bound to hemoglobin

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8
Q

PO2 does not directly tell us what

A

How much oxygen is in the blood

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9
Q

Dissolved oxygen is measured clinically as

A

PaO2

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10
Q

Henry’s law of gas solubility

A

C = KHP

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11
Q

Dissolved oxygen gives us how much O2 per min

A

15 mL O2 per min

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12
Q

How much oxygen do we need per minute

A

250 mL O2/min

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13
Q

Is dissolved O2 alone enough for us to live

A

lol no

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14
Q

If we have 100% oxygen, does that give the dissolved oxygen enough to be what we need

A

lol no

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15
Q

Hemoglobin has how many heme groups

A

4

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16
Q

Oxygenated blood is what color

A

R E D

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17
Q

Deoxygenated blood is what color

A

B L U E

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18
Q

Tense state

A

No oxygen bound, low affinity for oxygen

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19
Q

Relaxed state

A

Oxygen bound, high affinity

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20
Q

Oxygen binding is what kind of binding

A

Cooperative

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21
Q

Arterial blood Hb saturation is what percentage

A

98%

22
Q

Venous blood Hb saturation is what percentage

A

75%

23
Q

At PO2 > 60, what kind of changes are there in Hb saturation

A

Small changes in Hb saturation. Facilitates normal O2 transport to organs/cells

24
Q

At PO2 < 60 mmHg, small changes in pressure lead to what

A

Release of large amounts of O2. Facilitates release to organs/cells

25
Q

What is the significant threshold for hypoxemia intervention

A

60 mmHg

26
Q

Left shift of the Hb curve means what for O2 binding

A

Increased Hb-O2 binding

27
Q

Right shift for Hb curve means what for O2 binding

A

Decreased Hb-O2 bidning

28
Q

What will shift the curve left

A

Decrease in temp, PCO2, and 2,3-DPG

Increase in pH

29
Q

What will shift the curve right

A

Increase in temp, PCO2, and 2,3-DPG

Decrease in pH

30
Q

What is the cheat code

A

As factor X increases, Hb binding of oxygen decrease (temp, CO2, H+, 2,3-DPG)
Everything except CO

31
Q

2,3-DPG will what

A

Preferentially bind to de-oxygenated Hb and decreases affinity of Hb for oxygen

32
Q

What factors together provide the greatest shift of the Hb curve?

A

CO2 and DPG together

33
Q

Affinity of CO for Hb is _________ compared to affinity of O2

A

> 200 times greater compared to affinity of O2

34
Q

In the presence of CO, what happens to O2

A

Affinity for O2 is enhanced and unloading is prevented

35
Q

CO will force Hb into what state

A

The relaxed state, so higher affinity for O2

36
Q

Sickle cell disease

A

Single AA substitution in beta chain, HbS is normal with oxygen, will crystalize at low oxygen

37
Q

Hemoglobin and diabetes

A

Hemoglobin A1c, so increased blood glucose means more G6P, so more glycosylated Hb

38
Q

PaO2 > 80 mmHg means what

A

HYPOXEMIA

39
Q

PaO2 = 60 mmHg means what

A

DANGER !!!

40
Q

What is just as dangerous as altering your oxygen intake

A

Altering Hb saturation

41
Q

To calculate the oxygen content in the arterial blood (CaO2)

A

Multiply O2 capacity by the SO2

42
Q

Normal blood has what content at 100% saturation

A

20.1 mL O2/100 mL at SO2 100%

43
Q

CO2 is carried in the blood in 3 forms

A

Dissolved
Bicarbonate
Carbamino compounds

44
Q

Is there more dissolved CO2 or O2?

A

There is 20 times more dissolved CO2 than O2

45
Q

Increasing PO2 does what for Hb affinity for CO2

A

Decreases Hb affinity for Co2

46
Q

Decreasing PO2 does what for Hb affinity for CO2

A

Increases

47
Q

Haldane effect

A

Effect of O2 on Hb to increase/decrease CO2 binding. Unloading of CO2 in lungs

48
Q

Bohr effect

A

Effect of CO2 on Hb to increase/decrease O2 binding. Unloading of O2 in tissue

49
Q

Anemic hypoxia is what

A

Reduction in capacity of blood to carry oxygen

50
Q

Diffusion hypoxia

A

Reduction in circulation and subsequent oxygen delivery

51
Q

Histotoxic hypoxia

A

Tissues are poisoned, not able to use oxygen

FHB Mikayla (26 decks)

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