Unit 2, L14 Principles of Tubular Transport Flashcards

1
Q

Simple Diffusion

A

Move from high to low concentration, passive transport

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2
Q

Channel-mediated transport

A

Molecules that are specifically selected for those channels will move through when the channels are open, passive transport

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3
Q

Transporter-mediated transport

A

Requires a transporter to move, but is still passive transport as no energy is needed, the molecule is moving down its concentration gradient

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4
Q

Active transport

A

Moving against the concentration gradient of the molecule, requires energy in the form of ATP

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5
Q

Transcellular pathways

A

Moving through the cell itself, by simple diffusion so passive transport

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6
Q

Paracellular pathway

A

Bypassing the cell, doesn’t enter into the cell. There are adhesion junctions that provide some specificity that prevents everything from getting through, but some of the solutes get through

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7
Q

If moving using a paracellular pathway, is that against or with its concentration gradient?

A

With its concentration gradient

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8
Q

Primary active transport

A

Hydrolysis of ATP produced by mitochondria, gives energy that pushes the chemical out, against its concentration gradient

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9
Q

Secondary active transport

A

Movement of the molecule against its concentration gradient, coupled with the movement of a second molecule. Can move in an antiport fashion, which is going against its concentration gradient AND opposite of the second molecule, or in symport fashion, which is going against its concentration gradient and the same direction of the second molecule

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10
Q

What is the primary active transporter and what is it transporting

A

Na/K/ATPase, and moving Na out and K in, both of which is moving against its concentration gradient

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11
Q

What functions first, primary or secondary active transport?

A

Primary

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12
Q

Active or passive, carrier mediated, uses metabolic energy, and dependent on Na+ gradient:

Simple Diffusion

A

Passive, downhill
Not carrier mediated
Does not use metabolic energy
Is not dependent on Na+ gradient

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13
Q

Active or passive, carrier mediated, uses metabolic energy, and dependent on Na+ gradient:

Facilitated Diffusion

A

Passive and downhill
Yes, carrier mediated
No, does not use metabolic energy
No, is not dependent on Na+ gradient

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14
Q

Active or passive, carrier mediated, uses metabolic energy, and dependent on Na+ gradient:

Primary active transport

A

Active and uphill
Yes, is carrier mediated
Yes, directly uses metabolic energy
No, not dependent on Na+ gradient

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15
Q

Active or passive, carrier mediated, uses metabolic energy, and dependent on Na+ gradient:

Cotransport

A

Secondary active (Na+ is transported down hill and one or more solutes are transported uphill)
Yes, carrier mediated
Yes, indirectly uses metabolic energy
Yes, dependent on Na gradient as solutes move in the same direction as Na+ across cell membrane

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16
Q

Active or passive, carrier mediated, uses metabolic energy, and dependent on Na+ gradient:

Countertransport

A

Secondary active (Na+ is transported downhill and one or more solutes are transported uphill)
Yes, carrier mediated
Yes, indirectly uses metabolic energy
Yes, dependent on Na+ gradient as solutes move in opposite direction as Na+ across cell membrane

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17
Q

If something is moving by simple diffusion, what is the one thing that can limit its movement

A

Its concentration

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18
Q

At low solute concentrations, what is happening with binding sites and rate of transport

A

Many binding sites are available and the rate of transport increases steeply as the concentration increases

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19
Q

At high solute concentrations, what happens with binding sites and transport

A

At high solute concentrations, the available binding sites become less available and when all the binding sites are occupied, saturation is achieved

20
Q

What is the transport maximum

A

When all binding sites are occupied and saturation is achieved

21
Q

What percentage of free filtered glucose is reabsorbed back into the blood?

22
Q

Na-glucose co-transporter (SGLT)

A

Secondary active transport, it brings Na and glucose into the cell

23
Q

GLUT 1 and GLUT 2 transporters

A

Enable glucose to move across the basal membrane, only moves glucose

24
Q

With normal diets and being healthy, what is the normal level of glucose

A

200 mg/dL of glucose

25
At lower concentrations of glucose, what does the reabsorption and filtration amounts look lie?
Reabsorbed parallels filtered, so all filtered glucose is reabsorbed
26
When glucose concentration reaches renal plasma threshold, what happens to the filtered, reabsorbed, and excreted amounts
Filtered still continues in a linear line Reabsorbed starts to plateau, as we hit the RPT Excreted begins here, starts to increase and spill over into the urine
27
At the highest plasma glucose concentration, what happens to the excreted line, reabsorbed line, and filtered line
Filtered line continues linearally Reabsorbed line continues with its plateau Excreted line continues and becomes parallel with the filtered line, as all the excess is being excreted rather than reabsorbed
28
What is the tubular maximum of glucose transport
Tm = 375 mg/min
29
What is the renal plasma threshold value
RPT = 220 mg/dL
30
When RPT is reached, what type of transporters are saturated
The lowest capacity transporters
31
What is a region of splay (think glucose titration curve_)
Region of splay is defined from the RPT to the plasma concentration when Tm is reached
32
What are the transporters that are the last to saturate and have the highest capacity?
SGLT-1
33
Glucosuria
Whenver the renal plasma threshold for glucose is exceeded, glucose will be found in the urine. This leads to excretion or spilling of glucose in the urine
34
For PAH titration curve, what do the filtered, excreted, and secreted lines look like?
Filtered line is linear Excreted line is above the filtered line because PAH appearing in urine comes from both filtration and secretion Secreted line raises linearly until Tm, where it plateaus out
35
Pi for starling forces across peritubular capillary wall
Interstitial hydrostatic pressure
36
P pc for peritubular capillary wall (starling forces)
Peritubular capillary hydrostatic pressure
37
Pi i, starling forces for peritubular capillary wall
Interstitial fluid oncotic pressure
38
Pi PC, starling forces for peritubular capillary wall
Peritubular capillary oncotic pressure
39
In the peritubular capillaries, what happens with the starling forces?
First, solute and water are reabsorbed across apical membrane into the epithelial cell Second, some solute and water reenter the tubule fluid Third, most of the solute and water will move into the interstitium space, where it will go into the capillary
40
What is the main driving force for uptake to the peritubular capillaries
oncotic pressure in the peritubular capillaries
41
Major force opposing uptake to the peritubular capilarries
Hydrostatic pressure in peritubular capillaries, its 20
42
Overall, in the peritubular capillaries, what is the direction of fluid movement (starling forces)
Favors driving fluids into the capillaries
43
These starling forces only apply to the _______ and not the rest of the tubule system due to the permeability of water
Proximal tubule
44
Reabsorption of water and salt in the proximal tubule is __________
Isosmotic
45
Glomerulotubular balance
Where Na reabsorption in the proximal tubule varies in parallel with the filtered load, so 2/3 of the filtered Na is reabsorbed in the PT, even if GFR varies
46
What is the pathway for glomerulotubular balance
Increase GFR, leads to increase filtration fraction, leads to increased filtered load, leads to increased peritubular capillary reabsorption Decrease GFR leads to decrease filtration fration, leading to decreased peritubular capillary reabsorption