Unit 1.4

Question 1

Ibuprofen, ketoprofen, and naproxen are all derived from the same compound. What is that compound?

Answer 1

propionic acid

Question 2

Term means that the drug reduces fever

Answer 2

antipyretic

Question 3

Term that means that the adverse effect of a drug is NOT predictable because the factors that predispose the animal to toxicity are not known; incidence appears to be random.

Answer 3

idiosynctratic

Question 4

Which of the 5 COX-2 selective NSAIDs was the first one approved for veterinary use?

Answer 4

carprofen

Question 5

Non-selective COX inhibitor that has been used for decades in horses to relieve pain from musculoskeletal inflammation; has caused bone marrow suppression and tissue necrosis if injected IM or SQ.

Answer 5

phenylbutazone

Question 6

Non-selective COX inhibitor that is part of a larger group of compounds called salicylates; used to reduce platelet clumping.

Answer 6

aspirin

Question 7

Selective COX-2 inhibitor approved for use in cats only in the U.S.

Answer 7

robenacoxib

Question 8

Propionic acid derivative, OTC, NSAIDs not used much except in horses because of the fairly high incidence of side effects and the availability of safer NSAIDs (3 drugs).

Answer 8

ibuprofen, naproxen, ketoprofen

Question 9

Non-selective COX inhibitor drug that is used for its analgesic purposes in equine colic; also appears to block the effects of endotoxins generated during colic.

Answer 9

flunixin meglumine

Question 10

Non-selective COX inhibitor drug used as granules to feed horses; accumulates in horse joints to reduce lameness with joint inflammation and degenerative joint disease

Answer 10

meclofenamic acid

Question 11

Antiinflammatory that is NOT an anti-prostaglandin drug but works by inactivating destructive superoxide radicals that normally damage tissues

Answer 11

dimethyl sulfoxide

Question 12

Antiinflammatory that is absorbed through the skin; can carry other toxins or chemicals with it when it is absorbed; smell awful

Answer 12

dimethyl sulfoxide

Question 13

Not an antiinflammatory but an antipyretic drug with analgesic properties and less risk for GI tract adverse side effects

Answer 13

acetaminophen

Question 14

antidote for acetaminophen toxicosis

Answer 14

acetylcysteine

Question 15

T or F

Salicylates cause platelets to more readily clump together to promote faster clotting

Answer 15

False

Question 16

T or F
Ibuprofen, ketoprofen, and naproxen are generally recommended for use in dogs more than deracoxib, carprofen, and meloxicam

Answer 16

False

Question 17

T or F

DMSO inhibits prostaglandins as its primary mechanism of action

Answer 17

False

Question 18

T or F

Acetaminophen works primarily by blocking COX-2 activity

Answer 18

False

Question 19

T or F

Acetaminophen would be more likely to produce gastric ulcers than aspirin

Answer 19

False

Question 20

T or F

Phenylbutazone causes suppression of neutrophil and platelet production.

Answer 20

True

Question 21

COX-2 selective NSAIDs (6 drugs)

Answer 21

carprofen, etodolac, deracoxib, meloxicam, firocoxib, robenacoxib