Unit 1.3

Question 1

What does COX stand for?

Answer 1

cyclooxygenase

Question 2

What does LOX stand for?

Answer 2

lipoxygenase

Question 3

This kidney condition can result when an animal is hypotensive and an NSAID has been used

Answer 3

renal papillary necrosis

Question 4

Term that means that the adverse effect of a drug is not predictable because the factors that predispose the animal to toxicity are not known; incidence appears to be random

Answer 4

idiosyncratic

Question 5

T or F

NSAIDs decrease the activity of cyclooxygenase

Answer 5

True

Question 6

T or F

COX 1 generally produces beneficial prostaglandins

Answer 6

True

Question 7

T or F

COX 2 produces prostaglandins typically associated with the effects of inflammation

Answer 7

True

Question 8

T or F
NSAIDs that block COX 2 more than COX 1 would be more likely to produce GI ulcers and gastritis than NSAIDs that block COX 1 more than COX 2.

Answer 8

False

Question 9

T or F

NSAIDs are just as strong analgesics as the opioid analgesics.

Answer 9

False

Question 10

T or F

Under conditions of hypoproteinemia, the dose of NSAIDs should be increased to compensate

Answer 10

False

Question 11

T or F

NSAIDs block prostaglandins that normally cause vasodilation of the renal blood supply.

Answer 11

True

Question 12

T or F
Renal papillary necrosis occurs because blood flow to the kidney is decreased from the combination of hypotension and the use of NSAIDs.

Answer 12

True

Question 13

T or F

Hepatic side effects are more common than GI side effects with NSAIDs.

Answer 13

False