Unit 1: Homeostasis and Disease Chapter 1 Flashcards
Pathophisiology study breaks down into what 4 parts?
- Etiology (idiopathic, latrogenic)
- Pathogenesis
- Clinical manifestations
- Treatment
What is Etiology?
The cause(s) of the disease
What is Pathogenisis?
The process(s) in which the disease arises
What are clinical manifestations?
Signs and symptoms of the disease or presentation of the disease
What is pathology?
Is the study and diagnosis of diseases through examination of organs, tissues, cells and bodily fluids
What is physiology?
It is the study of the mechanical, physical, and biochemical functions of living organisms
What is pathophysiology?
Refers to the study of abnormalities in physiologic functioning of living beings
How are etiology and pathogenesis used to predict clinical manifestations and response to therapy?
Although not every host will respond the same to an infection, with research done on how a phenoma arises and the cause of it, clinical manifestations are somewhat predictable
Homeostasis
Tendency to stability in the normal internal environment of the body
Allostasis
Body’s mechanism to maintain homeostasis (normal part of homeostatic process).
*Homeostasis is end point, allostasis is the process.
Allostatic Load
The wear and tear on our body from over or under-activation of our body’s compensatory mechanisms
Allostatic Overload
“Cost” to the body organs and tissues from allostatic or compensatory responses that are excessive or not adequately regulated
Describe the difference between allostasis, allostatic load and allostatic overload.
With allostasis, an example can include that getting out of bed and doing exercise stimulates allostasis, as your body is adapting with a new heart rate (higher). Allostatic load and overload come in when repeated elevation of bP can then lead to negative effects.
Sign vs. Symptom
Sign: Objective
Symptom: Subjective
Examples of homeostatic imbalances
Thermoregulation, diabetes, cancer, dementia, depression
