Ulcer Drugs and Appetite Stimulents

Question 1

Magnesium Hydroxide: brand name, effects (3), use, administration

Answer 1

Milk of Magnesia

Raises rumen pH

Neutralizes HCl in monogastrics

Laxative effect

Treat rumen/gastric ulcers

PO

Question 2

Famotidine: brand name, effect, uses (2)

Answer 2

Pepcid

Blocks histamine-2 receptors in gastric mucosa –> reduces HCl production which raises gastric pH

Treat gastritis and esophagitis

Treat gastric or esophageal ulcers

Question 3

Sucralfate: brand name, effect, use, effectiveness

Answer 3

Carafate

Coats ulcers and helps prevent further damage, not absorbed systemically

Treat gastric, esophageal, and duodenal ulcers

Works best on an empty stomach, apart from antacids

Question 4

Misoprostol: type of drug, effects (2), use, caution

Answer 4

Prostaglandin

Stimulates gastric mucosal defense mechanisms

Reduces HCl secretions

Treat gastric ulcers, especially caused by NSAIDs

Usual reproductive hormone cautions

Question 5

Omeprazole: brand names (3), type of drug, effect, use

Answer 5

Prilosec - OTC enteric coated tablets

Ulcergard - OTC paste, prevents ulcers in horses

Gastrogard - Rx paste, treats ulcers in horses

Proton pump Inhibitor

Inhibits H+ transport, decreases HCl secretions

Prevent and treat stomach ulcers

Question 6

Appetite Stimulants: use, effectiveness

Answer 6

SA when anorexia does not respond to therapy for underlying tx

Will not work if it is nauseous

Question 7

Cyproheptadine: effect, uses (2)

Answer 7

Anti-serotonin and antihistamine

Appetite stimulus in SA

Treat serotonin syndrome

Question 8

Mirtazapine: effect, use, dosing, side effects (2)

Answer 8

Increase norepinephrine

Stimulates appetite in SA

Use at lowest effective dose to avoid adverse effects

Sedation

Serotonin syndrome

Question 9

Capromorelin: brand names (2), effect, use

Answer 9

Entyce (dogs), Elura (cats)

Ghrelin receptor agonist

Appetite stimulant in SA