Immunomodulating Drugs

Question 1

Cyclosporine: brand name, effect, use

Answer 1

Atopica

Suppresses cell-mediated immune response

Reduction of atopic inflammation and pruritis

Question 2

Oclacitinib: brand name, effect, use

Answer 2

Apoquel

Prevents activation of cytokines responsible for allergic inflammation and pruritis

Reduction of atopic inflammation and pruritis in dogs (eldu in cats)

Question 3

Lokivetmab: brand name, effect, use, administration

Answer 3

Cytopoint

Monoclonal antibody therapy - binds and neutralizes cytokine responsible for the “itch” signal

Control atopic pruritis in dogs

SQ once monthly

Question 4

Histamine receptors: H1 vs H2

Answer 4

H1 - anti-inflammatory and immune system effects

H2 - increases HCl secretion in the stomach

Question 5

Antihistamines: effect, uses (3)

Answer 5

H1 receptor antagonists - only effective before histamine binds to receptor

Prevent allergic reactions

One of the drugs used to treat acute hypersensitivity reactions

Long term atopy management

Question 6

Antihistamines: potential side effects (2)

Answer 6

Sedation

Irritability

Question 7

Diphenhydramine: name brand, effect, OTC/Rx?

Answer 7

Benadryl

H1 receptor antagonist

OTC

Question 8

Chlorpheniramine: effect, OTC/Rx?

Answer 8

H1 receptor antagonist

OTC

Question 9

Fexofenadine: effect, OTC/Rx?

Answer 9

H1 receptor antagonist

OTC

Question 10

Cetirizine: effect, OTC/Rx?

Answer 10

H1 receptor antagonist

OTC

Question 11

Hydroxyzine: effect, OTC/Rx?

Answer 11

H1 receptor antagonist

Rx

Question 12

Trimeprazine: brand name, effect, OTC/Rx?

Answer 12

Temaril-P (combined with prednisolone)

H1 receptor antagonist

Rx

Question 13

Tripelennamine: effect, OTC/Rx?

Answer 13

H1 receptor antagonist

Rx