Antifungals

Question 1

Antifungals: common side effects

Answer 1

GI upset

Hepatopathy

Question 2

Antifungals: mechanisms of actions (3)

Answer 2

Inhibits synthesis of ergosterol - safest, mammals don’t have this

Inhibit cell division

Disrupt cellular metabolism

Question 3

Ketoconazole: use, administration (2)

Answer 3

Otitis or dermatitis caused by Malassezia spp.

Topical - Otic, dermal

PO

Question 4

Itraconazole: uses (2)

Answer 4

Superficial mycoses, including dermatophytosis

System mycoses

Question 5

Terbunafine: use

Answer 5

Superficial mycoses, including dermatophytosis

Question 6

Griseofulvin: brand name, use, administration, side effects (2)

Answer 6

Fulvicin

Dermatophytosis only

PO - with a fatty meal or corn oil

High risk!

Hepatopathy

Bone marrow suppression

Question 7

Amphotericin B: use, side effect/caution

Answer 7

Serious systemic mycoses that do not respond to other antifungals

Very narrow therapeutic index

High risk of renal toxicity, even at appropriate dose