Bacitracin, Aminoglycosides, and Tetracyclines

Question 1

Bacitracin: method of action, effect, spectrum, administration

Answer 1

Inhibits cell wall growth

Bactericidal

Narrow spectrum

Topical: skin and ophthalmic

Part of NeoPolyBac

Question 2

Aminoglycosides: mechanism of action, effect, spectrum, administration

Answer 2

Disrupts protein synthesis

Bactericidal

Narrow spectrum

Injectable

Topical

Not absorbed PO

Question 3

Aminoglycosides: uses (2), cautions (2)

Answer 3

Soft tissue infects when the benefit outweighs the toxicity risk

Topical bacterial infections

Very narrow therapeutic index, toxicity can happen at appropriate doses

Nephrotoxicity

Ototoxicity

Question 4

Gentamicin: type of drug, Administrations (4)

Answer 4

Aminoglycosides

Injectable

Ophthalmic

Otic

Dermal

Question 5

Amikacin: type, administratiin

Answer 5

Aminoglycosides

Injectable

Question 6

Neomycin: type, administration (3), formulation, caution

Answer 6

Aminoglycosides

Ophthalmic

Otic

Dermal

Part of NeoPolyBac/Dex

Possible hypersensitivity rxn in cats

Question 7

Tetracyclines: mechanism of action, effect, spectrum, uses (2)

Answer 7

Disrupt protein synthesis

Bacteriostatic

Broad, but resistance is seen in older tetracyclines. Still useful for specific families

Rickettsial infections (ticks, salmon flukes)

Bacterial URIs

Question 8

Tetracyclines: cautions (2)

Answer 8

Will stain permanent teeth yellow if given before they erupt

Oral tabs/capsules risk esophageal stricture if they get stuck in the throat - chase with food or water

Question 9

Oxytetracycline: administration (2)

Answer 9

Injectable

Opthalmic - cats with bacterial URIs

Question 10

Doxycycline: species, administration (2)

Answer 10

PO - do not give with dairy products! Ca+ binds to rx and inactivates it

Injectable