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OLD "MIC 661" > Type IV HSRs > Flashcards

Type IV HSRs Flashcards

1
Q

What are delayed type IV HSRs?

A

contact/skin permeable antigen activates TH1 cells leading to activation of macrophages

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2
Q

Why are delayed type IV HSRs “delayed”?

A

requires the activation and recruitment of macrophages

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3
Q

What happens in the sensitization phase of delayed type IV HSRs?

A

recognition, processing, presentation by MHC II
T cell activation and expansion
T memory cells made

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4
Q

What are the 3 types of T memory cells?

A

central
effector
resident

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5
Q

Where are central T memory cells located?

A

circulation/SLT

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6
Q

Where are effector T memory cells located?

A

circulation/SLT and tissue

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7
Q

Where are resident T memory cell located?

A

peripheral tissue

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8
Q

CD45RA is expressed on what cells?

A

naive T cells

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9
Q

CD45RO is expressed on what cells?

A

all T memory cells

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10
Q

CCR7 is expressed on what cells?

A

naive T cells
central memory T cells

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11
Q

CD103 is expressed on what cells?

A

resident memory cells

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12
Q

Where are monocytes located?

A

blood

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13
Q

Where are macrophages located?

A

tissue

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14
Q

What happens in the effector phase of delayed type IV HSRs?

A

APC present and activate T memory cells = IFN-g and TNF production = macrophage/monocyte recruitment

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15
Q

What does IL-12 do in the DT4HSR inflammatory loop?

A

induces more TH1 cells

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16
Q

What does TNF do in the DT4HSR inflammatory loop?

A

macrophage activation and vascular permeability

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17
Q

What does IL-8 do in the DT4HSR inflammatory loop?

A

recruits neutrophils

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18
Q

What does CCL2 do in the DT4HSR inflammatory loop?

A

recruits monocytes

19
Q

Chronic macrophage activation due to the inability to clear antigen results in __________

A

granulomas

20
Q

What 2 things can induce granulomas formation?

A

silica
sutures

21
Q

What cytokines play a critical role in formation of granulomas and tissue damage?

A

IFN-g
TNF
(macrophage recruitment and release iNOS)

22
Q

TB skin test (mycobacterium) induce a pure _____ response

A

TH1

23
Q

Delayed type IV HSR are TH___ mediated

A

TH1

24
Q

Poison oak can be a TH___ mediated response but also a TH___

A

TH1
TH17

25
Q

What are 2 ways CD8 cells can be activate by DCs?

A
  1. sequential activation
  2. cross presentation
26
Q

What is sequential activation?

A

DC —CD4 T cell interaction increases B7 levels, then DC interacts/activates CD8 T cell

27
Q

What is cross presentation of CD8 T cells?

A

DC—CD4 T cell interactions, then changes their antigen processing to present on MHC I which can activate CD8 T cells
(present extracellular antigen on MHC I)

28
Q

What is it called in cross presentation when DC switches thier antigen processing to present on MHC I?

A

cytosolic diversion

29
Q

TCR don’t just recognize the peptide they also recognize _______

A

MHC

30
Q

What 2 things are special about NKT cells?

A
  1. expresses invariant TCR (no memory)
  2. senses glycolipids only
31
Q

NKT cells recognize ____ presented by ____ on APCs

A

glycolipids
CD1d

32
Q

NKT cells DO NOT recognize…

A

MHC–peptide complex

33
Q

How does CD1a present lipids differently than how MHC presents peptides?

A

lipid is buried in CD1d and the A’ roof is what is recognized

34
Q

What expresses CD1a?

A

LC DCs

35
Q

What causes A’ roof to be blocked in CD1a?

A

healthy skin lipid head causes steric hinderance

36
Q

In the interference model of CD1a, binding of TCR is soley based on _____ not _____

A

CD1a not ligand

37
Q

What linkage in skin is abnormal in atopic dermatitis?

A

fillagrin

38
Q

What are corneocytes?

A

keratinocytes without nucleus

39
Q

Where are regular LC DCs located?

A

epidermis

40
Q

When LC DCs sample a foreign lipid with its CD1a what T cell subset is produced?

A

TH17

41
Q

How does the skin sense PPD from TB skin test?

A

injected directly into dermis by passing LC DCs and being sensed by dermal DCs and macrophages

42
Q

Only CD1___ has an A’ roof

A

CD1a

43
Q

What are 2 delayed type IV HSRs?

A
  1. PPD (TB skin test)
  2. urushiol (poison oak)

OLD "MIC 661" (19 decks)

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