Inflammation Flashcards
1
Q
What are the 3 inflammatory cytokines?
A
- TNF-a
- IL-6
- IL-1B
2
Q
What is the role of TNF-a?
A
master regulator
- increases vascular permeability
- increases adhesion molecules
(RA, DT4HSR)
3
Q
What is the role of IL-6?
A
produce acute phase proteins
(RA)
4
Q
What is the role of IL-1B?
A
fever response
(RA)
5
Q
What cells produce the inflammatory cytokines?
A
macrophages
6
Q
What does TNF-a induce when high concentrations are in the blood?
A
anaphylaxis
7
Q
What are acute phase proteins?
A
present in blood and rise or fall in [ ] in response to inflammation
8
Q
What is an example of a acute phase protein?
A
CRP
9
Q
What 2 things are special about IL-1B?
A
- leaves cell only through leakage
- does not requires transcription
10
Q
What are the 3 functions of neutrophils?
A
- phagocytosis
- degranulation
- NETosis
11
Q
What is PAD4?
A
citrullinates proteins by changing charge on Arg from positive to neutral = auto-antigen
