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OLD "MIC 661" > Exam 1 Condensed > Flashcards

Exam 1 Condensed Flashcards

1
Q

What is the mechanism of anti-IgE therapy?

A

binds to Fc region of IgE to prevent binding to FcERI on granulocytes

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2
Q

What is the mechanism of anti-IL5 therapy?

A

binds to soluble IL-5 preventing it from binding to IL-5R on eosinophils

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3
Q

What is the mechanism of anti-IL5Ra therapy?

A

binds to IL-5Ra on eosinophils and induces ADCC

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4
Q

What asthma therapy dramatically reduces eosinophil levels in the blood?

A

Anti-IL-5Ra

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5
Q

What is the mechanism of anti-IL4Ra therapy?

A

binds to IL-4Ra preventing IL-4 from binding

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6
Q

Does anti-IL4Ra decrease eosinophils in the tissue?

A

yes (in the lungs) to prevent degranulation

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7
Q

Does anti-IL4Ra decrease eosinophils in the blood?

A

no (as long as they aren’t in the tissue its fine)

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8
Q

What is the mechanism of anti-IL4 AMG317?

A

binds to IL-4Ra preventing IL4 from binding

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9
Q

Why does anti-IL4 AMG317 not work?

A

poor pharmacokintetics (antibody is not able to get where its suppose to)

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10
Q

What is the mechanism of anti-IL13 therapy?

A

binds to soluble IL-13 and prevents it from binding to IL-4/13 receptor (type II)

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11
Q

Why does anti-IL13 therapy not work?

A

IL-4 is able compensate for IL-13 (since they share the same receptor)

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12
Q

What is the mechanism of anti-TSLP therapy?

A

binds to TSLP preventing CD4+ cells from committing to Th2 lineage

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13
Q

What is special about TSLP?

A

its an epithelial cytokines

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14
Q

What are the up-regulated cytokines in atopic dermatitis?

A

IL-13

IL-36
IL-22
IL-20
IL-19
IL-10

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15
Q

What are the up-regulated cytokines in psoriasis?

A

IL-17

IL-36
IL-24
IL-22
IL-20
IL-19
INF-g

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16
Q

What cytokine is the most dominant in AD?

A

IL-13

17
Q

What cytokine is the most dominant in psoriasis?

A

IL-17

18
Q

What are the 3 distinct features of AD?

A
  1. epithelial barrier dysfunction
  2. susceptibility to infection
  3. atopic features (asthma)
19
Q

How is atopic dermatitis heterogenetic?

A

Th2 activation is prominent in all ethnic groups but the immune polarization is different in ethnic groups

20
Q

What is a good treatment for just AD?

A

anti-IL13 because its the prominent cytokine in AD

21
Q

What is a good treatment for AD and asthma at the same time?

A

anti-IL4Ra because its target IL-13 (AD) and IL-4 (asthma)

22
Q

What is the AD mechanism for african americans?

A

increased IgE/Th2 mediated
FLG mutation is less serve

23
Q

What is Q576R mutation in african americans?

A

causes augmented IL-4Ra leading to worsened asthma

24
Q

What is the mechanism for AD in Asians?

A

Th17/IL-22 mediated
FLG mutation more prominent

25
Q

What ethinc group is most affected by the FLG mutation?

A

europeans

26
Q

What is the shared trait between AD and psoriasis?

A

Th1/IFN-g mediated inflammatory response

OLD "MIC 661" (19 decks)

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