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OLD "MIC 661" > Psoriasis v. AD > Flashcards

Psoriasis v. AD Flashcards

1
Q

Psoriasis is TH___ mediated

A

TH17

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2
Q

AD is TH___ mediated

A

TH2

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3
Q

AD is a ______ reaction while psoriasis __________ disorder

A

AD: HSR
psoriasis: autoimmune

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4
Q

What are 3 alterations of skin in psoriasis?

A

redness
skin thickening
white scales

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5
Q

Because of the dysfunction of skin in psoriasis what 3 things occur making it a skin barrier dysfunction disease?

A

improper skin stacking
improper secretion of lipids
improper adherence of keratinocytes

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6
Q

Are keratinocytes or T cells the driving force of psoriasis?

A

TH17 cells

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7
Q

What APC is important in psoriasis?

A

pDCs

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8
Q

The basic dysfunction of psoriasis is _________ imbalance

A

lipid

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9
Q

IL-___ is the most important cytokine for psoarisis

A

IL-17

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10
Q

Atopic dermatitis is IL-___ dominant while psoriasis is IL-___ dominant

A

IL-13
IL-17

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11
Q

HLA___ is a risk factor for psoriasis

A

HLA -B27

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12
Q

What are the 3 functions of IFN-a?

A
  1. anti-viral
  2. immunomodulator (increased MHC expression)
  3. anti-proliferative
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13
Q

What signaling pathway does IFN-a use?

A

JAK/TYK

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14
Q

How does anti-BCDA2 decrease psorasis?

A

prevents pDCs from secreting cytokines (INF-a)

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15
Q

How does TYK2 inhibitors decrease psorasis?

A

prevents JAK/TYK signaling pathway of IFN-a

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16
Q

What are 2 markers for pDCs?

A

BCDA2/CD123
CD86

17
Q

What is the best drug target for AD?

A

anti-IL4Ra

18
Q

What is the mutation in FLG cause?

A

broken epidermis layer allowing microbes and allergens in

19
Q

How do CD8+ T cells play a role in psoriasis?

A

kill the keratinocytes
(located in epidermis)

20
Q

What receptor is important in psoriasis and why?

A

IL-2Ra (type II high affinity)
T cell proliferation

21
Q

HLA C06 and B07 are HLA class ____ and are risk factors in psoriasis

A

HLA class I

22
Q

What is the difference in B cells in psoriasis and AD?

A

psoriasis: no Ab
AD: elevated IgE

23
Q

What are the 2 main differences in psoriasis and AD?

A

AD: skin barrier dysfunction
psoriasis: overactive keratinocytes

AD: HSR (innocuous antigen)
psoriasis: auto-immune (no antigen)

OLD "MIC 661" (19 decks)

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