Psoriasis v. AD Flashcards
Psoriasis is TH___ mediated
TH17
AD is TH___ mediated
TH2
AD is a ______ reaction while psoriasis __________ disorder
AD: HSR
psoriasis: autoimmune
What are 3 alterations of skin in psoriasis?
redness
skin thickening
white scales
Because of the dysfunction of skin in psoriasis what 3 things occur making it a skin barrier dysfunction disease?
improper skin stacking
improper secretion of lipids
improper adherence of keratinocytes
Are keratinocytes or T cells the driving force of psoriasis?
TH17 cells
What APC is important in psoriasis?
pDCs
The basic dysfunction of psoriasis is _________ imbalance
lipid
IL-___ is the most important cytokine for psoarisis
IL-17
Atopic dermatitis is IL-___ dominant while psoriasis is IL-___ dominant
IL-13
IL-17
HLA___ is a risk factor for psoriasis
HLA -B27
What are the 3 functions of IFN-a?
- anti-viral
- immunomodulator (increased MHC expression)
- anti-proliferative
What signaling pathway does IFN-a use?
JAK/TYK
How does anti-BCDA2 decrease psorasis?
prevents pDCs from secreting cytokines (INF-a)
How does TYK2 inhibitors decrease psorasis?
prevents JAK/TYK signaling pathway of IFN-a
What are 2 markers for pDCs?
BCDA2/CD123
CD86
What is the best drug target for AD?
anti-IL4Ra
What is the mutation in FLG cause?
broken epidermis layer allowing microbes and allergens in
How do CD8+ T cells play a role in psoriasis?
kill the keratinocytes
(located in epidermis)
What receptor is important in psoriasis and why?
IL-2Ra (type II high affinity)
T cell proliferation
HLA C06 and B07 are HLA class ____ and are risk factors in psoriasis
HLA class I
What is the difference in B cells in psoriasis and AD?
psoriasis: no Ab
AD: elevated IgE
What are the 2 main differences in psoriasis and AD?
AD: skin barrier dysfunction
psoriasis: overactive keratinocytes
AD: HSR (innocuous antigen)
psoriasis: auto-immune (no antigen)
