Quiz 1 Flashcards
1
Q
What is an innocuous antigen?
A
should not induce an allergy response
2
Q
What are atopic individuals?
A
predisposed to allergies
3
Q
What is the hygiene hypothesis?
A
lack of early childhood exposure to infectious agents, gut flora, and parasites increases susceptibility to allergic diseases
4
Q
What is intrauterine IPEX?
A
fetal immune system cannot discriminate self antigens (lack of FoxP3=no Tregs)
5
Q
When are TGF-B highest?
A
fetal development
6
Q
When is immune tolerance development high?
A
fetus
7
Q
High levels of TGF-B means high or low levels of Tregs?
A
high levels
8
Q
What is the largest mucosal surface and contains the most microbes?
A
intestinal epithelial
9
Q
What is tonic signaling?
A
immune skewing above baseline set by the barrier surface microbiome and other factors
