type 3 hypersensitivity Flashcards
type 3 hypersensitivity is what type of reaction
immune (antigen-antibody) complex
mediated
what happens during type 3 hypersensitivity
Complexes are formed in the circulation and
deposited later in vessel walls or
extravascular tissues.
type 3 hypersensitivity is not _____ specific
is not organ specific
what does type 3 hypersensitivity damage result from
results from complement activation
and neutrophil lysosomal enzymes.
what are the 3 types of immune complex clearance
large; small; intermediate
what is the large immune complex clearance
macrophages
what is the small immune complex clearance
renal clearance
what is the intermediate immune complex clearance
deposited in tissues; causes problems
what is type 3 hypersensitivity characterized by
variety of symptoms
what periods occurs during type 3 hypersensitivity
periods of remission or exacerbation occur
what are some examples of type 3 hypersensitivity
serum sickness
arthus reaction
what is an example of serum sickness
Raynaud phenomenon
what tissues in the body are affected by serum sickness
blood vessels; joints; and kidney
_______ causes some areas of the body — such as fingers and toes — to feel numb and cold in response to cold temperatures or stress. smaller arteries that supply blood to the skin narrow. This limits blood flow to affected areas, which is called vasospasm.
Raynaud phenomenon
what is arthus reaction
Localized response causes increased
vascular permeability,
an accumulation of neutrophils, edema, hemorrhage, clotting, and tissue damage