type 3 hypersensitivity Flashcards

1
Q

type 3 hypersensitivity is what type of reaction

A

immune (antigen-antibody) complex
mediated

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2
Q

what happens during type 3 hypersensitivity

A

Complexes are formed in the circulation and
deposited later in vessel walls or
extravascular tissues.

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3
Q

type 3 hypersensitivity is not _____ specific

A

is not organ specific

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4
Q

what does type 3 hypersensitivity damage result from

A

results from complement activation
and neutrophil lysosomal enzymes.

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5
Q

what are the 3 types of immune complex clearance

A

large; small; intermediate

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6
Q

what is the large immune complex clearance

A

macrophages

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7
Q

what is the small immune complex clearance

A

renal clearance

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8
Q

what is the intermediate immune complex clearance

A

deposited in tissues; causes problems

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9
Q

what is type 3 hypersensitivity characterized by

A

variety of symptoms

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10
Q

what periods occurs during type 3 hypersensitivity

A

periods of remission or exacerbation occur

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11
Q

what are some examples of type 3 hypersensitivity

A

serum sickness
arthus reaction

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12
Q

what is an example of serum sickness

A

Raynaud phenomenon

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13
Q

what tissues in the body are affected by serum sickness

A

blood vessels; joints; and kidney

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14
Q

_______ causes some areas of the body — such as fingers and toes — to feel numb and cold in response to cold temperatures or stress. smaller arteries that supply blood to the skin narrow. This limits blood flow to affected areas, which is called vasospasm.

A

Raynaud phenomenon

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15
Q

what is arthus reaction

A

Localized response causes increased
vascular permeability,

an accumulation of neutrophils, edema, hemorrhage, clotting, and tissue damage

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