type 1 hypersensitivity Flashcards

1
Q

what type of reaction is type 1 hypersensitivity

A

immunoglobulin E (IgE) mediated

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2
Q

type 1 hypersensitivity reacts against

A

environmental antigens (allergens)

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3
Q

what happens during type 1 hypersensitivity

A

IgE binds to crystalline fragment (Fc) receptors on the surface of mast cells;
cross linking causes the release of histamine from mast cell degranulation

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4
Q

what are the receptors involved in type 1 hypersensitivity

A

h1and h2 receptors

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5
Q

what does type 1 hypersensitivity increase

A

chemotactic activity

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6
Q

what are the manifestations from h1 receptor

A

bronchial constriction
edema
vasodilation

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7
Q

what are the manifestations from h2 receptor

A

increases gastric secretions
decreases release of histamine from mast cells and basophils

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