type 1 hypersensitivity Flashcards
what type of reaction is type 1 hypersensitivity
immunoglobulin E (IgE) mediated
type 1 hypersensitivity reacts against
environmental antigens (allergens)
what happens during type 1 hypersensitivity
IgE binds to crystalline fragment (Fc) receptors on the surface of mast cells;
cross linking causes the release of histamine from mast cell degranulation
what are the receptors involved in type 1 hypersensitivity
h1and h2 receptors
what does type 1 hypersensitivity increase
chemotactic activity
what are the manifestations from h1 receptor
bronchial constriction
edema
vasodilation
what are the manifestations from h2 receptor
increases gastric secretions
decreases release of histamine from mast cells and basophils