hypersensitivity classifications

Question 1

type 1 hypersensitivity is what type of reaction

Answer 1

IgE

Question 2

which hypersensitivity causes the release of histamine (most potent mediator) and other inflammatory responses

Answer 2

type 1

Question 3

what does histamine release lead to

Answer 3

edema (swelling)

Question 4

type 2 hypersensitivity is what kind of reaction

Answer 4

tissue specific

Question 5

type 2 hypersensitivity is caused by

Answer 5

5 possible mechanisms (complement mediated lysis, opsonization and phagocytosis, neutrophil mediated tissue damage, antibody dependent cell mediated cytotoxicity, modulation of cellular function

Question 6

what type of reaction is type 3 hypersensitivity

Answer 6

immune complex mediated reactions (e.g lupus)

Question 7

what causes type 3 hypersensitivity

Answer 7

the formation of immune
complexes deposited in target tissues where they activate the complement cascade
generating chemotactic fragments that attract neutrophils into the inflammatory
site. Neutrophils release lysosomal enzymes resulting in tissue damage

Question 8

what type of reaction is type 4 hypersensitivity

Answer 8

cell mediated

Question 9

what cells causes type 4 hypersensitivity

Answer 9

caused by either cytotoxic T lymphs (TC cells) or
lymphokine producing Th1 cells