type 2 hypersen Flashcards
main points
tissue specific
antibody mediated
mainly cytotoxic
first step
escaped self reactive b cells produce igm or cd4 helps it to porudce igg
extrinisc antifen
infection/ medication like penicillin
intrinsic antigen
antigen host makes
process of penicillin ove reeaction
binds to RBC
egg/igm may bind to molecule creating an antigen antibody complex
mechanism 1
activation of complicment system
I’m/g activates compliemnt proteins which kill the rbc
c3,4a,5a attract neutrophils which degranulate and release 02 radicals which are cytotoxic causing tissue damage
example of i=condition
haemolyytic anaemia
mechanism 2
formation of MAC molecule by different compliment protwins
function of MAC
attacks cell by inserting self into membrane, cell swells and dies
test for haemolytic anemia
coombs test