cytokines Flashcards
where are mHC class ones found
on all nucleated cells
where are mhc2 foun d
on antigen presenting cells; macrophages, monocytes aand dendritic cells
paracrine
cytokine produced by one cell and affects ones in near vicinity
endocrine
cytokine affects far away cell
autocrine
cell producing cytokine is also the one responding
what is IL-2 secreted by
CD4
role of IL-2
helps prolif of t lymphocytes
type 1 interferons
IFN-alpha and IFN-beta
type 2 Interferons
IFN-gamma
role of IFN-gamma
activates CD4
role of IL-12
acitvates NK cells
helps CD4 differentiate into TH1
IL-8 role
helps move cells towards site of inflammation
whta produces and releases crp
IL-6
what acts on liver and brain
IL-1, IL-6, TNF-alpha
what does TNF-allpha cause
vasodilation and increased vascular permeability
fight against parasitic infections
IL-4,5,,13
function of IL-1
produces acute inflammation and fever
what cell produces IL-2
t cells
function of IL-4
class switchiong to IgG and IgE
what produces IL-4
Th2 cells
what cell secretes IL-5
Th2
function of IL-6
Th17 maturation, fever and inflammation
what cell produces TNF-alpha
macrophages
function of iL-5
activates eosinophils
what produces il-6
macrophages
function of IL-8
chemotaxis for neutrophils
main source of IL-9
macrophages
what cell produces IL-10
th2
What is the function of Interferon-gamma
To activate macrophages
What cell produces interferon-gamma?
Th1
what cell produces IL-1
macrophages
function of IL-10
Anti-inflammatory cytokine which inhibits TH1 cytokine production
What is the function of TNFalpha
Chemotaxis for neutrophil and induces fever
