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immunology > cytokines > Flashcards

cytokines Flashcards

1
Q

where are mHC class ones found

A

on all nucleated cells

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2
Q

where are mhc2 foun d

A

on antigen presenting cells; macrophages, monocytes aand dendritic cells

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3
Q

paracrine

A

cytokine produced by one cell and affects ones in near vicinity

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4
Q

endocrine

A

cytokine affects far away cell

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5
Q

autocrine

A

cell producing cytokine is also the one responding

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6
Q

what is IL-2 secreted by

A

CD4

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7
Q

role of IL-2

A

helps prolif of t lymphocytes

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8
Q

type 1 interferons

A

IFN-alpha and IFN-beta

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9
Q

type 2 Interferons

A

IFN-gamma

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10
Q

role of IFN-gamma

A

activates CD4

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11
Q

role of IL-12

A

acitvates NK cells
helps CD4 differentiate into TH1

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12
Q

IL-8 role

A

helps move cells towards site of inflammation

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13
Q

whta produces and releases crp

A

IL-6

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14
Q

what acts on liver and brain

A

IL-1, IL-6, TNF-alpha

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15
Q

what does TNF-allpha cause

A

vasodilation and increased vascular permeability

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16
Q

fight against parasitic infections

A

IL-4,5,,13

17
Q

function of IL-1

A

produces acute inflammation and fever

18
Q

what cell produces IL-2

A

t cells

19
Q

function of IL-4

A

class switchiong to IgG and IgE

20
Q

what produces IL-4

A

Th2 cells

21
Q

what cell secretes IL-5

A

Th2

22
Q

function of IL-6

A

Th17 maturation, fever and inflammation

23
Q

what cell produces TNF-alpha

A

macrophages

24
Q

function of iL-5

A

activates eosinophils

25
Q

what produces il-6

A

macrophages

26
Q

function of IL-8

A

chemotaxis for neutrophils

27
Q

main source of IL-9

A

macrophages

28
Q

what cell produces IL-10

A

th2

29
Q

What is the function of Interferon-gamma

A

To activate macrophages

30
Q

What cell produces interferon-gamma?

A

Th1

31
Q

what cell produces IL-1

A

macrophages

32
Q

function of IL-10

A

Anti-inflammatory cytokine which inhibits TH1 cytokine production

33
Q

What is the function of TNFalpha

A

Chemotaxis for neutrophil and induces fever

34
Q
A

immunology (14 decks)

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