intro Flashcards
what response is responsible for fever
innate
response for memory
adaptive
Haematopoiesis
formation of white and red blood cells
granulocytes
basophils
neutrophils
eosinophils
what does bone marrow produce during immune response
neutrophils which [hagocytose by using granules or oxidative burst
what do granules fuse with
phagosome to form phagolysosome
what do granules contain
molecules that lower the ph of the phagolysosome making it very acidic whcih kills some pathogens
oxidative burst
when the neutrophil keeps swalloing pathogens it produces highly reactive oxygen species
action of reactive oxygen species
destroy proteins and nucleic acids within phagolysosome; pathogen eliminated
what do eosinophils stain
pink with eosin
what type of cells are eosinophils
phagocytic
eosinophils best known for
fighting helminths and in allergic reactions
what do basophils stain
blue with hematoxylin
are basophils phagocytic
no
what do basophils contain
histmaine
what are importannt in initiating allergic repsonses
basophils due to having histamine
mast cells
live in tissues no blood
non phagocytic
what releases cytokines
monocytes, macrophages and dendritic cells
cytokines
molecules which attract other immune cells to area
where do monocytes circulate
blood
what happens to monocytes when they migrate into tissues
turn into macrophages
where are macropjages found
tissues
immature dendritic cells
good at phagocytosing
mature dendritic cell
when it phagocytosis’
action of dendritic cells
breaks up pathogen contents into short amino acids then moves to nearets lymph mnode and present antigen to t cells
what connects innate with adaptive
dendritic cells presnting to t cells
priming
when t cell wtih specific receptor to antigen of denrittic cell binds
how do denritic cells present to t cells
on a mhc molecule
where do b and natural killer cells mature
bone marrow
where do some lymphoid progenitor cells migrate
to thymus where they develop into t cells
NK cells
large lymphocytes with granules
how do nk cells kill their target cells
by releasing cytotocic granules
can b cells present antigens to t cells
yes on mhc 2
how are b cells matured into plasma cells
by t cells post b cells have presented antigens to them
CD4T cells
helper t cells
antigen presented on mhc 2 molecule
cd8+
cytoxic t cells
presented by Mhc 1
what can nk cells target
viruses and cancer cells
