innate Flashcards
what hapens if a pathogen enters
begins with macrophage recognizing by the molecules it has on its surface
PAMPS
molecules on pathogens
what are pamps composed of
peptidoglycan and LPS
what are pamps recognized by
PRRS
what happens post recogniztion
prrs bind to pamps for phagocyte to gobble it up but dont alloq for cytokines to be released yet so macrophage can investogate
if only little amoount of pathogens
then phagocytic PRRS become activates and eliminate them
what happens when macrophage gobbles up bacteria
traps it in a vesicle called a phagosome
what does the phagosome fuse with
lysosome to form phagolysosome
what happens if there are lots of pathogens around
phagocytes need helps and signalling prr comes in
signalling prrs
get macrophages to release cytokines
tnf alhpha
cytokine produced by macrophages/ monocytes