compliment pathway

Question 1

crp role

Answer 1

primes certain bacteria for destruction by the complement system

Question 2

crp use

Answer 2

ussed as a marker for inflammation

Question 3

first step of

Answer 3

c3 becomes active and is cleaved into c3b and c3a

Question 4

how is c3 cleaved

Answer 4

through mannose binding lectin binding to manose it undergoes a conformational change whihc is able to cleave c3

Question 5

what might c3b do

Answer 5

bind to bacterium and become stable

Question 6

what happens once c3b binds

Answer 6

can then activate more proteins via the alternative pathway

Question 7

alternative pathway

Answer 7

c3b being able to amplify c3 into c3a and c3b again

Question 8

how is c5 convertase produced

Answer 8

by c3b binding with other coomplement system proteins

Question 9

what happens once c5 is active

Answer 9

cleaves c5b and c5a

Question 10

active c5b role

Answer 10

associates with other complement system proteins to produce a pore forming channel ; MAC

Question 11

MAC

Answer 11

Membrane attack complex
extracellular slatsand water enter the pathogen via this pore cauing it to swell

Question 12

anaphylatoxins

Answer 12

c3aa and c5a promote changes in vasulaturw and acitvate mast cells

Question 13

powerful opsonin

Answer 13

c3b