immunodeficiency

Question 1

b cell defects

Answer 1

Reduced numbers of peripheral blood B cells
Absent / reduced levels of serum Igs

Question 2

how do b cells become partially activated

Answer 2

id they encounter an antigen that their specific BCR can bind to

Question 3

X-linked agammaglobulinemia

Answer 3

mutations in the BTK gene; X-linked recessive inheritance (males)

Pathogenesis: Block in differentiation & development of pre-B cells
Absence or severe reduction in B lymphocytes & Igs of all types

Question 4

XSCID

Answer 4

Mainly in males
failure of t cell and nk function

Question 5

main target for hIV

Answer 5

CD4

Question 6

mediates acute and chornic organ rejection

Answer 6

cytotoxic t cells and t helpers

Question 7

mediates hyperacute organ rejectoin

Answer 7

b cells