Autoimmunity

Question 1

autoimmunity

Answer 1

presence of immune responses agaisnt sel antigens

Question 1

how are antibodies generated

Answer 1

by the production of heavy chain and light chain

Question 2

central tolerance

Answer 2

Deletion of self-reactive lymphocytes in primary lymphoid tissues

Question 3

peripheral tolerance

Answer 3

Regulatory T cells (TREG cells) can help inactivate auto-reactive lymphocytes in peripheral tissues that escape central tolerance

Question 4

graves disease

Answer 4

type 2 hypersensiitvty

Question 5

type 3 hypersensiitvy diseases

Answer 5

Systemic lupus erythematosus (SLE)
Rheumatoid arthritis (secondary to disease driven by type IV reactions)
Glomerulonephritis (some types)

Question 6

type 4 diseases

Answer 6

Heart - autoimmune myocarditis
Pancreas - diabetes mellitus type 1
Thyroid - Hashimoto’s thyroiditis
Nervous system - multiple sclerosis
Musculoskeletal system - rheumatoid arthritis