TYPE 2 DIABETES Flashcards

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1
Q

what is the cellular compensation that initially occurs with t2diabetes

A

hyperinsulinaemia

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2
Q

after years of hyperinsulinaema what develops

A

beta cell exhaustion

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3
Q

what is beta cell exhaustion

A

beta cells initally compensate by pumping out a lot of insulin btu eventually the cells run out of steam and they cant compensate anymore = lack of insulin and target cells become completely resistant to insulin

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4
Q

describe the insulin level throughout the course of t2diabetes

A

initially - high levels
later - significant fall in levels

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5
Q

what is it a slower onset for t2 diabetes

A

because it will be longer before a pt is assymptomatic, as they will be insulin resistant before they are diabetic

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6
Q

what are the clinical features of type 2 diabetes

A

hyperglycaeia
glycosuria
diabetic neuropathy
diabetic vascular disease

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7
Q

is hyperglycaemia an immune supressor

A

yes

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8
Q
A
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