tx

Question 1

melanoma

Answer 1

	Cured if detected early
	Drugs that target RAS and P13K/AKT pathways
	BRAF inhibitors
	Anti-CTLA4 blocking antibodies
	Anti-PD1 blocking antibodies

Question 2

actinic keratosis

Answer 2

o Local eradication is indicated.
o Curettage, freezing or topical chemo.
o Topical imiquimod activates TLRs and eradicates 50% of lesions (via activation of immune cells).

Question 3

BCC

Answer 3

Tx targeting the inhibition of Hedgehog pathway have excellent responses in pts with locally aggressive or metastatic dz.

Question 4

Dermatofibrosarcoma Protuberans

Answer 4

o Wide local excision.
o If unresectable d/t location or spread, use PDGFβ inhibitors (imatinib drug d/c and tumor recurs so pts use this drug for life)

Question 5

Acute Eczematous Dermatitis

Answer 5

Tx with steroids is palliative (not curative), need to remove offending substance from the environment.

Question 6

phemigus

Answer 6

immunosuppression