morph

Question 1

nests of nevus cells at the dermoepidermal junction

Answer 1

Junctional melanocytic nevus

Question 2

nests or cords of melanocytes extend into the underlying dermis

Answer 2

Compound melanocytic nevus

Question 3

complete loss of nests.

Answer 3

Intradermal melanocytic nevus

Question 4

coalescent nests of nevus cells

Answer 4

dysplastic nevi

Question 5

Lentiginous melanocyte hyperplasia

Answer 5

dysplastic nevi

Question 6

Linear papillary dermal fibrosis d/t melanin incontinence

Answer 6

dysplastic nevi

Question 7

hyperplasia of pigmented basaloid cells and hyperkeratosis; Keratin filled horn cysts

Answer 7

seborrheic keratosis

Question 8

 Basaloid cells with trichilemmal/hair-like differentiation.
 Similar to germinal portion of normal hair bulb in anagen growth phase

Answer 8

Pilomatrixomas

Question 9

o	Tan-brown-red or flesh colored lesions < 1 cm.
o	Rough consistency.
o	Intercellular bridges 
o	Elastosis:
o	Parakeratosis

Answer 9

actinic keratosis

Question 10

o	Firm, brown-tan papules.
o	Occasionally tender.
o	Lateral compression → inward dimpling
o	spindle shaped fibroblasts in a well-defined, mid-dermal non-encapsulated mass
o	Pseudoepithliomatous hyperplasia

Answer 10

Benign Fibrous Histiocytoma (dermatofibroma)

-Pseudoepithliomatous hyperplasia: Downward elongation of hyperpigmented rete ridges

Question 11

o	Firm nodules that are protuberant.
o	Storiform pattern
o	Overlying epidermis is thin
o	Honeycomb pattern
o	Infiltrates subcutis like "Swiss Cheese"

Answer 11

Dermatofibrosarcoma Protuberans
o Storiform pattern: Closely packed fibroblasts arranged radially (pinwheel appearance).
o Honeycomb pattern: Extension into SQ fat

Question 12

Sezary-lutzner cells

Answer 12

Mycosis Fungoides (Cutaneous T-cell Loma (CTCL)
=(hallmark): Malignant CD4+ Th cell with a hyperconvoluted (cerebriform) nuclei.

Question 13

Pautrier microabscesses.

Answer 13

Mycosis Fungoides (Cutaneous T-cell Loma (CTCL)
=band like dermal infiltrates with single cell invasion into the epidermis

Question 14

spindle and stellate cells with toluidine blue or Giemsa stains to see granulessystemic mastocytosis

Answer 14

systemic mastocytosis

Question 15

o edema and occasional dermal eos, but nfs are rare.
o Widely spaced collagen bundles.
o Dilation of superficial lymphatic channels

Answer 15

Urticaria (hives)

Question 16

• Red, papulovesicular, oozing and crusted lesions.

- spongiosis

Answer 16

Acute Eczematous Dermatitis

Question 17

CD8 in ctr, CD4 in periphery

Answer 17

Erythema Multiforme

Question 18

Targetoid lesions:

Answer 18

Erythema Multiforme
=Red, maculopapular lesions with central pallor d/t necrosis of keratinocytes with associated perivenular inflamm (interface dermatitis).

Question 19

~ test tubes in a rack

Answer 19

psoriasis

=Epidermal prolif : epidermal thickening (canthosis) w downward elongation of rete ridges

Question 20

Auspitz sign:

Answer 20

psoriasis

=dilated vessels of underlying dermal papillae → pinpoint bleeds if overlying scale is removed.

Question 21

spongiform pustules.

Answer 21

psoriasis

Question 22

Munro microabscesses

Answer 22

psoriasis

Question 23

Wickham striae: white dots or lines (hypergranulosis) on tha papules

Answer 23

lichen planus

Question 24

Interface dermatitis:

Answer 24

lichen planus
=dense, bandlike, dermalepidermal junction lymphocytic infiltrate with basal cell degeneration and necrosis and jagged rete sawtoothing.

Question 25

Colloid/Civatte bodies:

Answer 25

lichen planus

=necrotic basal cells sloughed into inflamed papillary dermis

Question 26

IgG deopsits, Suprabasal acantholytic blister (‘row of tombstones’).

Answer 26

phemigus vulgaris

Question 27

superficial IgG

Answer 27

phemigus foliaceus

Question 28

Abs to BPAG2

Answer 28

Bullous Pemphigoid

Question 29

Neutrophils and fibrin accumulate in the tips of dermal papillae → small microabscesses.
–> Basal vacuolization overlies the microabscesses and coalesces to large subepidermal blisters.

Answer 29

dermatitis herpetaformis

Question 30

o Flushing (pre-rosacea).
o Persistent erythema and telangiectasia.
o Pustules & papules: Nfs colonize follicles → granulomatous dermal response.
o Rhinophyma: permanent thickening of nasal skin via confluent erythematous papules and prominent follicles d/t sebaceous hyperplasia and follicular plugging by keratotic debris.

Answer 30

roseaca

Question 31

cathelicidin

Answer 31

roseaca

Question 32

inflamm and vasc dilation

Answer 32

roseaca

Question 33

Primary vasculitis of deep vessels supplying fat lobules of the subcutis.

Answer 33

erythema induratum

Question 34

Erythematous macule that progress to small pusutues then to shallow erosions w a honey-colored crust.

Answer 34

impetigo