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Radiographically: large, destructive, lytic & blastic mass with infiltrative margins: sunburst pattern
osteosarcoma
Leontiasis ossea (lion face)
Pagets dis (osteitis deformans) =Enlargement of craniofacial skeleton (frontal bone), heavy cranium difficult to hold up
and symp
leiomyosarcoma
Platybasia
Pagets dis (osteitis deformans) =Invagination of the skull base → compression of the posterior fossa
warms overlying skin
Pagets dis (osteitis deformans) -d/t Hypervascularity of bone (acts as AV shunt)
no bony reaction, over 2cm, in vert column; pain not relieved by asa
osteobalstoma
TB arthritis
Tuberculosis Spondylitis (Pott Disease) (Mycobacterial Osteomyelitis )
Saddle nose
Skeletal Syphilis (congenital)
sinus tract formation
Tuberculosis Spondylitis (Pott Disease) (Mycobacterial Osteomyelitis )
High output CF (if severe)
Pagets dis (osteitis deformans)
Irregular or nodular thickening of the palmar fascia u/l or b/l.
Puckering and dimpling of the skin may occur over years.
Slow, progressive flexion contracture affects the 4th and 5th digits of the hand.
Dupuytren Contracture (palmar) subtype superficial fibromatosis
vert fx, painful, loss ht, dowagers hump
osteoporosis
Micromelic shortening o flimbs, fromntal bossing, macrocephaly, small chest cavity, bell-shaped abd => resp insufficiency
Thanatophoric dysplasia
painful, enlarging mass (tender, warm, swollen); systemic s/s mimicking infxn (fever, elevated ESR, anemia, leukocytosis)
Ewing Sarcoma Family Tumors (ESFT) (including PNET)
Compression fx of spine → kyphosis
Pagets dis (osteitis deformans)