Tumour Lysis Syndrome Flashcards
1
Q
What is tumour lysis syndrome?
A
Symptoms caused by massive tumour cell lysis
2
Q
What happens in tumour cell lysis?
A
Release of
- potassium
- phosphate
- uric acid
3
Q
What are the features of TLS?
A
Raised uric acid Raised potassium Raised phosphate AKI Low calcium
4
Q
What are the symptoms of TLS?
A
N+V
Anorexia
Haematuria -> oliguria -> anuria
Arrhythmias
5
Q
What are risk factors for TLS?
A
Pre-existing renal dysfunction
Pre-treatment raised urea
Hypovolaemia
Pre-treatment diuretic use
6
Q
How is TLS managed?
A
Rehydration
Rasburicase
+/- dialysis
7
Q
How is TLS prevented?
A
Allopurinol
Rasburicase
8
Q
How does allopurinal work?
A
Lowers uric acid
9
Q
How does rasburicase work?
A
rasburicase = urate oxidase
Converts uric acid to allantoin which is more easily excreted
