Tumors of uncertain histogenesis

Question 1

what is another name for GIANT CELL TUMOR?

what is this tumor made up of?

on who is this seen?

how does it look on imaging?

Answer 1

osteoclastoma

first due to osteoclasts then become multinucleated giant cells and stromal cells.

young adult females

soap-bubble appearance

Question 2

a Giant Cell tumor will usually arise in what bone part?

Answer 2

epyphysis of long bones (distal femur, proximal tibia, distal radius)

Question 3

Ewing Sarcoma is what?

where does it appear?

is it pediatric or adult tumor?

how does it look on x-ray?

Answer 3

Malignant proliferation of poorly-differentiated cells derived from neuroectoderm.

diaphysis of long bones

pediatric

onion-skin appearance

Question 4

a biopsy of ewing sarcoma will reveal?

what genetic translocation leads to ewings sarcoma?

what is the usual presentation?

what other diseases can this look like?

Answer 4

small, round blue cells that resemble lymphocytes

11,22

fever, pain, swelling and metastasis

lymphoma or chronic osteomyelitis