Tumor Markers Flashcards
1
Q
α-Fetoprotien (AFP)
A
- Hepatocellular Carcinoma
- Yolk-sac tumor (testes)
2
Q
β-hcg
A
- Trophoblastic Tumors
- Choriocarcinoma
3
Q
Calcitonin
A
Medullary carcinoma of thyroid
4
Q
CEA (carcionic embryonic antigen)
A
- Carcinoma : Lungs, Pancreas, Stomach, Breast, Colon
5
Q
CA-125
A
Ovarian cancer
6
Q
CA19-9
A
Pancreatic cancer
7
Q
Placental Alk Phos
A
Seminoma (testes)
8
Q
PSA + Prostatic acid phosphatase
A
Prostate cancer
9
Q
S-100
A
- Melanoma
- Neural derived tumor
- Astrocytoma
10
Q
TRAP + , CD25+
A
Hairy cell Leukemia
11
Q
5-HIAA
A
Carcinoid tumor/ Syndrome
12
Q
Monoclonal IGs
A
- IgG = Multiple Myeloma
- Any IG = MGUS
13
Q
Catecholamines
A
Pheochromocytoma
14
Q
BRCA
A
Breast cancer
15
Q
C-myc
A
Burkitts Lymphoma
16
Q
BCL-2
A
Follicular & Undifferentiated Lymphoma
(Inhibits apoptosis)
17
Q
RET
A
Multiple endocrine neoplasia MEN type 2A & 2B
18
Q
N-myc
A
Neuroblastoma
19
Q
L-myc
A
Lung tumor
20
Q
RAS
A
Colon cancer
21
Q
C-kit
A
GI stromal tumor
22
Q
BCR-ABL
A
CML
23
Q
ERBB1 (EGFR)
A
Lung Adenocarcinoma
24
Q
RAS
A
- Cholangiocarcinoma
- Pancreatic adenocarcinoma
25
BRCA 1& 2
Breast & Ovarian cancer
26
APC / β- catenin
- Colon, Gastric & Pancreatic cancer
- Familial adenomatous polyposis
27
TP-53
- Most cancers
- Li-fraumeni syndrome
28
RB gene mutation
- Retinoblastoma
- Osteosarcoma
29
WT-1 gene mutation
Wilms tumor
30
VHL- gene mutation
- Renal cell carcinoma
- VHL syndrome
31
BCL-1
Mantle cell lymphoma, t(11:14)
32
CA 19-9
Pancreatic adenocarcinoma
33
Carcinoembryonic Antigen
Gastrointestinal (i.e. Colorectal CA)
34
Carcinoembryonic Antigen
Gastrointestinal (i.e. Colorectal CA)
35
HCG
- Choriocarcinoma
- Germ Cell tumors
