Tumor Markers Flashcards by Abdullah Bukhari

Q

α-Fetoprotien (AFP)

A

Hepatocellular Carcinoma
Yolk-sac tumor (testes)

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Q

β-hcg

A

Trophoblastic Tumors
Choriocarcinoma

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Q

Calcitonin

A

Medullary carcinoma of thyroid

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Q

CEA (carcionic embryonic antigen)

A

Carcinoma : Lungs, Pancreas, Stomach, Breast, Colon

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Q

CA-125

A

Ovarian cancer

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Q

CA19-9

A

Pancreatic cancer

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Q

Placental Alk Phos

A

Seminoma (testes)

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Q

PSA + Prostatic acid phosphatase

A

Prostate cancer

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Q

S-100

A

Melanoma
Neural derived tumor
Astrocytoma

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Q

TRAP + , CD25+

A

Hairy cell Leukemia

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Q

5-HIAA

A

Carcinoid tumor/ Syndrome

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Q

Monoclonal IGs

A

IgG = Multiple Myeloma
Any IG = MGUS

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Q

Catecholamines

A

Pheochromocytoma

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Q

BRCA

A

Breast cancer

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Q

C-myc

A

Burkitts Lymphoma

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Q

BCL-2

A

Follicular & Undifferentiated Lymphoma
(Inhibits apoptosis)

Q

RET

A

Multiple endocrine neoplasia MEN type 2A & 2B

Q

N-myc

A

Neuroblastoma

Q

L-myc

A

Lung tumor

Q

RAS

A

Colon cancer

Q

C-kit

A

GI stromal tumor

Q

BCR-ABL

A

CML

Q

ERBB1 (EGFR)

A

Lung Adenocarcinoma

Q

RAS

A

Cholangiocarcinoma
Pancreatic adenocarcinoma

Q

BRCA 1& 2

A

Breast & Ovarian cancer

Q

APC / β- catenin

A

Colon, Gastric & Pancreatic cancer
Familial adenomatous polyposis

Q

TP-53

A

Most cancers
Li-fraumeni syndrome

Q

RB gene mutation

A

Retinoblastoma
Osteosarcoma

Q

WT-1 gene mutation

A

Wilms tumor

Q

VHL- gene mutation

A

Renal cell carcinoma
VHL syndrome

Q

BCL-1

A

Mantle cell lymphoma, t(11:14)

Q

CA 19-9

A

Pancreatic adenocarcinoma

Q

Carcinoembryonic Antigen

A

Gastrointestinal (i.e. Colorectal CA)

Q

Carcinoembryonic Antigen

A

Gastrointestinal (i.e. Colorectal CA)

Q

HCG

A

Choriocarcinoma
Germ Cell tumors