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Personal Deck > Trimethoprim/Sulfamethoxazole/Nitrofurantoin/Fosfomycin > Flashcards

Trimethoprim/Sulfamethoxazole/Nitrofurantoin/Fosfomycin Flashcards

1
Q

Trimethoprim/Sulfamethoxazole is commonly used to treat:

A

UTI’s (prostatitis), PJP Pneumonia, community acquired MRSA

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2
Q

Trimethoprim/Sulfamethoxazole should be dosed for:

A

Renal: CrCl <30mL/min

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3
Q

Trimethoprim/Sulfamethoxazole can cause suppression of:

A

bone marrow

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4
Q

Trimethoprim/Sulfamethoxazole should NOT be used in:

A

Pregnancy (2nd or 3rd trimester) & lactating mothers

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5
Q

Trimethoprim/Sulfamethoxazole should be used with caution in:

A

Renal impairment

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6
Q

Is Trimethoprim/Sulfamethoxazole bactericidal or bacteriostatic?

A

bacteriostatic

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7
Q

How does Trimethoprim/Sulfamethoxazole work?

A

Inhibits synthesis of folate via dihydrofolate synthase

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8
Q

How do bacterias confer resistance against Trimethoprim/Sulfamethoxazole?

A

Mutations result in an overproduction of PABA which results in return of folate production

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9
Q

What is a major drug reaction with Trimethoprim/Sulfamethoxazole?

A

Warfarin

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10
Q

What electrolyte imbalance can occur with Trimethoprim/Sulfamethoxazole?

A

Hyperkalemia

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11
Q

Trimethoprim/Sulfamethoxazole is contraindicated in children:

A

younger than 2

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12
Q

What is the MOA of Nitrofurantoin?

A

Damages & inhibits cell wall synthesis

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13
Q

What is Nitrofurantoin primarily used for?

A

Uncomplicated UTI’s

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14
Q

Drug interactions for Nitrofurantoin:

A

Probenecid inhibits renal excretion

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15
Q

Nitrofurantoin Contraindications:

A

Pregnancy
Renal impairment

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16
Q

Nitrofurantoin should be ___ dosed:

A

Renal dosing: CrCl <30mL/min

17
Q

Fosfomycin indicated for:

A

UTI’s in women (cystitis)

18
Q

Fosfomycin MOA:

A

Cell wall synthesis inhibitor via pyruvil transferase

19
Q

If treating a pregnant patient with a UTI, 1st line treatment would be:

A

Fosfomycin

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