Influenza Drugs (Oseltamivir § Zanamivir)

Question 1

MOA (both):

Answer 1

They inhibit Neuramidase (normally cleaves viral attachment & allows spread) –> inhibition stops propagation

Question 2

ADR’s for Zanamivir:

Answer 2

Cough, SOB, Bronchitis

Question 3

Routes:

Answer 3

Oseltamivir Oral
Zanamivir Inhaler

Question 4

Absorption/Distribution:

Answer 4

Oseltamivir: Well absorbed
Zanamivir: 4-17%

Question 5

Metabolism/Excretion:

Answer 5

Oseltamivir: converted to active metabolite; 90%, excreted unchanged in urine

Zanamivir: Unchanged in urine

Question 6

Special considerations for Oseltamivir:

Answer 6

Poorly excreted and not expected to cause adverse in breastfeeding