Lincosamides

Question 1

What is the MOA of Clindamycin?

Answer 1

Binds to 50s ribosomal subunit and inhibits protein synthesis

Question 2

What drug classes is Clindamycin similar to based on MOA:

Answer 2

Macrolides & Oxazolidiones (Linezolid)

Question 3

Is Clindamycin bacteriostatic?

Answer 3

Yes

Question 4

Why is Clindamycin use limited?

Answer 4

High risk of GI disturbances d/t C.Diff overgrowth

Question 5

Blackbox warning for Clindamycin?

Answer 5

C.Diff overgrowth can cause Pseudomembranous colitis

Question 6

PO absorption of Clindamycin:

Answer 6

Complete absorption. Highly protein bound

Question 7

How is clindamycin distributed?

Answer 7

Distributes to pleural/peritoneal fluids with high concentrations in bile

Question 8

Clindamycin & Pregnancy

Answer 8

Safe to use. Crosses placenta & excreted in breast milk

Question 9

How is Clinda metabolized & excreted? Dose modifications required?

Answer 9

Metabolized in liver
Excreted in bile & urine
No dose adjustment unless severe impairments

Question 10

Important Drug Interactions for Clinda:

Answer 10

1. Erythromycin: (competes with Macrolides d/t mechanism of action)
2. Kaolin Pectin
3. Neuromuscular blockers

Question 10

What is clindamycin used for?

Answer 10

Bacterial endocarditis
Septic shock (decreases toxin production)
PJP PNA
Drug resistant pneumococcal infections