COVID 19 Drugs COPY Flashcards

1
Q

Nirmatrelvir MOA:

A

Prevents viral replication by inhibiting Mpro (main protease)

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2
Q

Nirmatrelvir ADR’s:

A

Dysgeusia, hypertension, myalgia, anaphylaxis, hypersensitivity reactions

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3
Q

Major Drug interactions for Nirmatrelvir:

A

Strong CYP3A inhibitor; interacts with drugs metabolized by this enzyme group

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4
Q

When taking Nirmatrelvir avoid concomitant use with drugs:

A

That may lead to serious or life-threatening reactions (e.g., alfuzosin, amiodarone, colchicine, simvastatin

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5
Q

Pharmacokinetics of Nirmatrelvir:

A

Peaks in plasma in 3 hours
60% protein bound

Minimally metabolized; excreted in urine and feces.

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6
Q

Ritonavir MOA:

A

Works concurrently with nirmatrelvir by inhibiting CYP3A and increasing its plasma concentration

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7
Q

Ritonavir Adverse Reactions:

A

hypertriglyceridemia, hepatotoxicity

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8
Q

Major Drug Interactions for Ritonavir:

A

Strong CYP3A inhibitor
Drugs that may lead to serious or life-threatening reactions (e.g., alfuzosin, amiodarone, colchicine, simvastatin

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9
Q

Pharmacokinetics for Ritonavir:

A

Peak plasma in 3.98 hours

98% to 99% bound to plasma proteins

Metabolized via CYP3A4 and CYP2D6; Excreted mainly in feces

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10
Q

What is Paxlovid?

A

Nirmatrelvir with Ritonavir together

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11
Q

Adverse Reactions for Paxlovid:

A

Dysgeusia, diarrhea, hypertension, myalgia, anaphylaxis.

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12
Q

Pharmacokinetics for Paxlovid:

A

Rapid absorption, high protein binding.

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13
Q

Major Drug Interactions for paxlovid:

A

Strong CYP3A inhibitor

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14
Q

Remdesevir MOA:

A

Inhibit COVID RNA dependent RNA polymerase & inhibits viral RNA synthesis.

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15
Q

ADR’s for Remdesevir:

A

elevated liver enzymes (ALT, AST), hypersensitivity reactions.

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16
Q

Major Drug interactions for Remdesevir:

A

May reduce the anticoagulant effect of warfarin.

17
Q

Remdesevir is contraindicated with these drugs:

A

chloroquine or hydroxychloroquine due to antagonistic effect.

18
Q

Kinetics of Remdesevir:

A

Rapid absorption; peak plasma concentration in 0.67 hours

88% to 93.6% bound to plasma proteins.

Prodrug metabolized into active metabolites

eliminated in urine.