COVID 19 Drugs COPY

Question 1

Nirmatrelvir MOA:

Answer 1

Prevents viral replication by inhibiting Mpro (main protease)

Question 2

Nirmatrelvir ADR’s:

Answer 2

Dysgeusia, hypertension, myalgia, anaphylaxis, hypersensitivity reactions

Question 3

Major Drug interactions for Nirmatrelvir:

Answer 3

Strong CYP3A inhibitor; interacts with drugs metabolized by this enzyme group

Question 4

When taking Nirmatrelvir avoid concomitant use with drugs:

Answer 4

That may lead to serious or life-threatening reactions (e.g., alfuzosin, amiodarone, colchicine, simvastatin

Question 5

Pharmacokinetics of Nirmatrelvir:

Answer 5

Peaks in plasma in 3 hours
60% protein bound

Minimally metabolized; excreted in urine and feces.

Question 6

Ritonavir MOA:

Answer 6

Works concurrently with nirmatrelvir by inhibiting CYP3A and increasing its plasma concentration

Question 7

Ritonavir Adverse Reactions:

Answer 7

hypertriglyceridemia, hepatotoxicity

Question 8

Major Drug Interactions for Ritonavir:

Answer 8

Strong CYP3A inhibitor
Drugs that may lead to serious or life-threatening reactions (e.g., alfuzosin, amiodarone, colchicine, simvastatin

Question 9

Pharmacokinetics for Ritonavir:

Answer 9

Peak plasma in 3.98 hours

98% to 99% bound to plasma proteins

Metabolized via CYP3A4 and CYP2D6; Excreted mainly in feces

Question 10

What is Paxlovid?

Answer 10

Nirmatrelvir with Ritonavir together

Question 11

Adverse Reactions for Paxlovid:

Answer 11

Dysgeusia, diarrhea, hypertension, myalgia, anaphylaxis.

Question 12

Pharmacokinetics for Paxlovid:

Answer 12

Rapid absorption, high protein binding.

Question 13

Major Drug Interactions for paxlovid:

Answer 13

Strong CYP3A inhibitor

Question 14

Remdesevir MOA:

Answer 14

Inhibit COVID RNA dependent RNA polymerase & inhibits viral RNA synthesis.

Question 15

ADR’s for Remdesevir:

Answer 15

elevated liver enzymes (ALT, AST), hypersensitivity reactions.

Question 16

Major Drug interactions for Remdesevir:

Answer 16

May reduce the anticoagulant effect of warfarin.

Question 17

Remdesevir is contraindicated with these drugs:

Answer 17

chloroquine or hydroxychloroquine due to antagonistic effect.

Question 18

Kinetics of Remdesevir:

Answer 18

Rapid absorption; peak plasma concentration in 0.67 hours

88% to 93.6% bound to plasma proteins.

Prodrug metabolized into active metabolites

eliminated in urine.