Oxazolidinones

Question 1

Oxazolidinones Drug Names

Answer 1

Linezolid (zyvox)

Question 2

Linezolid MOA

Answer 2

Binds to ribosomal 50s subunit, prevents formation of 70s initiation complex which inhibits protein synthesis

Question 3

Linezolid Susceptible Organisms

Answer 3

Aerobic, Gram-Positive

VRE, MRSA, Streptococcus

group A/B StrepS. pneumoniae, E. faecalis, E. faecium, S. Aureus MRSA/SA

Question 4

Linezolid Absorption

Answer 4

Rapid/complete after oral admin

Question 5

Linezolid Distribution

Answer 5

31% Protein Bound - Conc. Dependent
High concentration found in skin and well-perfused areas (exceeding plasma)

Question 6

Linezolid Metabolism

Answer 6

Nonenzymatic. Does not utilize CYP
Oxidation of morpholone ring creates 2 inactive metabolites of linezolid

Question 7

Linezolid Excretion

Answer 7

30% unchanged in urine
65% nonrenal excretion

Question 8

Use of these drugs & Linezolid is not recommended:

Answer 8

Pseudoephedrine
Vasopressors
Dopaminergics
MAOi’s

Question 9

Linezolid Considerations:

Answer 9

-Bone Marrow suppression
-Can be used in children
-Serotonin Syndrome

Question 10

Linezolid Indications

Answer 10

First Line VRE
Greater cure rates of MRSA than Vanco

Question 11

What foods should be avoided when taking Linezolid?

Answer 11

Tyramine rich foods: aged cheese, wine, beer, chocolate, caffeine

Question 12

Is Linezolid bactericidal?

Answer 12

No, bacteriostatic

Question 13

How is Linezolid similar to Clindamycin & Macrolides?

Answer 13

They all bind to 50s ribosomal subunit

Question 14

Seratonergic drugs that interact with Linezolid:

Answer 14

SSRI’s
TCA’s
Methadone
Ondansetron
Meperidine
Tramadol
Buspirone