Trimethoprim and nitros Flashcards
Trimethoprim mechanism
Inhibit dna synthesis
Dose of trimethoprim for UTI
200mg BD
Side effects of trimethoprim
Blood disorders
Skin reactions
Fungal overgrowth
Headache
Foetal abnormalities
What electrolyte imbalance does trimethoprim cause
Hyperkalaemia
What to monitor with trimethoprim long term
FBC
Caution of trimethoprim
Acute porphyria
Folate deficiency
Trimethoprim and pregnancy
Avoid
Trimethoprim egfr when to reduce dose
Half dose after 3 days if egfr 15-30
Half dose if egfr less than 15 straight away
What can happen after taking trimethoprim
Thrush or any fungal infection
T for thrush T for trimethoprim
When to avoid nitrofurantoin
Egfr less than 45
Pregnancy 3 trimester
Nitro dose men and pregnant women
100mg bd x 7 days
Nitro dose non pregnant females
100mg bd x 3 days
Why to avoid nitro at term
Neonatal haemolysis
What to do if egfr 30-44 with nitro
Reduce course to 3-7 days
Interaction of amiodarone and nitro
Peripheral neuropathy
Nitrofurantoin MHRA warning
Pulmonary and hepatic disorders
What colour does nitro make urine
Red / brown
How to take nitro
With food
When to stop using nitro
Reduced lung function or liver problem
Contraindications of nitro
G6pd deficiency
Acute porphyria
Infants less than 3 months
Caution nitro with
Anaemia
Reduced Vit b
Reduced folate
Electrolyte imbalance
Pulmonary disease
What drugs increase peripheral neuropathy with nitration
Amidoarone
Cisplatin
Metronidazole
Symptoms of peripheral neuropathy
Tingling hands and feet
Stabbing shooting pain
Loss of balance
Muscle weakness especially feet
What to test for before starting canakinumab
TB
