Trimethoprim and nitros

Question 1

Trimethoprim mechanism

Answer 1

Inhibit dna synthesis

Question 2

Dose of trimethoprim for UTI

Answer 2

200mg BD

Question 3

Side effects of trimethoprim

Answer 3

Blood disorders
Skin reactions
Fungal overgrowth
Headache
Foetal abnormalities

Question 4

What electrolyte imbalance does trimethoprim cause

Answer 4

Hyperkalaemia

Question 5

What to monitor with trimethoprim long term

Answer 5

FBC

Question 6

Caution of trimethoprim

Answer 6

Acute porphyria
Folate deficiency

Question 7

Trimethoprim and pregnancy

Answer 7

Avoid

Question 8

Trimethoprim egfr when to reduce dose

Answer 8

Half dose after 3 days if egfr 15-30

Half dose if egfr less than 15 straight away

Question 9

What can happen after taking trimethoprim

Answer 9

Thrush or any fungal infection
T for thrush T for trimethoprim

Question 10

When to avoid nitrofurantoin

Answer 10

Egfr less than 45
Pregnancy 3 trimester

Question 11

Nitro dose men and pregnant women

Answer 11

100mg bd x 7 days

Question 12

Nitro dose non pregnant females

Answer 12

100mg bd x 3 days

Question 13

Why to avoid nitro at term

Answer 13

Neonatal haemolysis

Question 14

What to do if egfr 30-44 with nitro

Answer 14

Reduce course to 3-7 days

Question 15

Interaction of amiodarone and nitro

Answer 15

Peripheral neuropathy

Question 16

Nitrofurantoin MHRA warning

Answer 16

Pulmonary and hepatic disorders

Question 17

What colour does nitro make urine

Answer 17

Red / brown

Question 18

How to take nitro

Answer 18

With food

Question 19

When to stop using nitro

Answer 19

Reduced lung function or liver problem

Question 20

Contraindications of nitro

Answer 20

G6pd deficiency
Acute porphyria
Infants less than 3 months

Question 20

Caution nitro with

Answer 20

Anaemia
Reduced Vit b
Reduced folate
Electrolyte imbalance
Pulmonary disease

Question 21

What drugs increase peripheral neuropathy with nitration

Answer 21

Amidoarone
Cisplatin
Metronidazole

Question 22

Symptoms of peripheral neuropathy

Answer 22

Tingling hands and feet
Stabbing shooting pain
Loss of balance
Muscle weakness especially feet

Question 23

What to test for before starting canakinumab

Answer 23

TB