Penicillins Flashcards

1
Q

Examples of penicillinase-resistant penicillins

A

Flucloxacillin

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2
Q

Examples of beta lactamase sensitive abx

A

Pen V (phenoxy)
Pen G (benzylpen)

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3
Q

Broad spec penicillin

A

Amoxicillin
Co amoxiclav
Ampicillin

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4
Q

Antipseudomonal penicillins

A

Piperacillin
Ticarcillin

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5
Q

Mecillinam type penicillin

A

Pivmecillinam

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6
Q

Which penicillin to take on empty stomach

A

Ampicillin
Fluclox
Phenoxy

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7
Q

Side effects of penicillins

A

Hypersensitivity
Nausea
Vomiting
Hepatic disorders (especially with fluxloc and co amoxiclav)

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8
Q

Max duration of pens

A

14 days

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9
Q

Side effect of co amoxiclav

A

Cholestaic jaundice
Thrombocytopenia
Increased risk of infection

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10
Q

Abx causing c diff

A

Clindamycin
Cephalosporins
Flouroquinolones
Broad spec abx

PPI (not abx)

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11
Q

Side effect of fluclox

A

Cholestatic jaundice which can occur even 2 months after stopping treatment
Hepatitis

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11
Q

Penicillin mechanism of action

A

inhibition of cell wall synthesis

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12
Q

Why should you avoid intrathecal route with penicillins

A

Encephalopathy risk

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13
Q

What route is benzylpenicillin

A

IV

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14
Q

Amoxicillin rare side effect

A

Black hairy tongue

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15
Q

Which patients higher risk of anaphylactic with amoxicillin

A

Patients with atopic allergies like hayfever eczema or asthma

16
Q

When to continue with penicillin rash

A

If occurs after 72 hours and not itchy or is small

17
Q

What condition should avoid penicillins

A

Glandular fever

18
Q

Abx colitis is common with what penicillins

A

Broad spec
(Cause build up of C diff - inflammation of colon)

19
Q

When to refer patient on penicillin

A

Rash - sign of anaphylaxis

20
Q

Penicillins interactions

A

WAM

Warfarin - increased bleed risk
Allopurinol - inc skin reaction risk
Methotrexate - inc toxicity as pens reduce excretion of methotrexate from kidneys

21
Q

Minimum age for phenoxy

A

6 years

22
Q

Benzylpenicllin (pen g) warning with injection

A
  • Accumulation of sodium at injection site
  • Inc risk of neurotoxicity with high dose - coma/convulsions
23
Q

Phenoxy main indication

A

Respiratory infections

24
Q

Phenoxy side effects

A

Neurotoxicity
Oral disorders
Increased infection risk
Coagulation disorder

25
Q

Which penicillins cause macropapular rash

A

Amoxicillin
Ampicillin

26
Q

Mechanism of Clauvanic acid

A

Beta lactamase inhibitor

27
Q

Who should avoid fluclox

A

Hepatic disorders

28
Q

Which abx cause cholestatic jaundice

A

Co amox
Fluclox