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Infections > Quinolones > Flashcards

Quinolones Flashcards

1
Q

Side effects of quinolones

A

QT prolongation (especially mifloxacin)
Hepatic severe (mefloxacin)
Psychiatric problems
Photosensitivity
CONVULSIONS
GI disturbances
Headache
Dizziness

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2
Q

Quinolones contraindications

A

History of convulsions
History of tendon damage
G6PD deficiency
Young children and adolescents (arthopathy)
Myasthenia gravis

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3
Q

Mechanism of action of quinolones

A

Inhibition of dna replication of bacteria

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4
Q

Should you avoid quinolones in pregnancy

A

Yes

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5
Q

Interaction between quinolones and nsaid

A

Increased risk of convulsions

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6
Q

Interaction between quinolones and steroids

A

Increased risk of tendon damage and tendinitis

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7
Q

Who more risk of developing tendon damage with quinolones

A

Over 60
Use of corticosteroids

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8
Q

What electrolyte imbalance does quinolones cause

A

Inc glucose in blood

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9
Q

Patient advise on quinolones

A

Avoid sunlight - photosensitive reactions up to 48h after stopping - stop asap

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10
Q

Why avoid quinolones in children or young adults or pregnancy

A

Arthropathy risk

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11
Q

Is quinolone effective against MRSA

A

No

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12
Q

When can risk of tendon damage happen

A

Within 48 hours

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13
Q

Moxifloxacin side effects

A

Life threatening hepatotoxicitty
Qt prolongation

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14
Q

When to discontinue fluoroquinolones

A

Tendon damage suspected
Photosensitivity
Psychiatric reactions

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15
Q

Ciprofloxacin side effect with theophylline

A

Inhibitor so increases theophylline conc which increases seizures

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16
Q

Quinolones should be avoided with what drink

A

Alcohol

17
Q

Which quinolones to protect from sunlight

A

Ofloxacin

18
Q

When to avoid aminoglycosides

A

If egfr less than 20

19
Q

MHRA symptoms of the quinolone

A

SUICIDAL THOUGHT

TENDON DAMAGE

SEIZURE

Infections (11 decks)

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