Macrolides

Question 1

Which macrolide has long half life so used once daily

Answer 1

Azirhromycin

Question 2

How to prevent nausea and vomiting with erythromycin

Answer 2

Give lower dose

Question 3

What electrolyte imbalance do macrolides cause

Answer 3

Hypokalameia

Question 4

Which macrolide safe in pregnancy and breastfeeding

Answer 4

Erythromycin

Question 5

Which eradication is clarithromycin used in

Answer 5

H pylori

(With Amox and metronidazole)

Question 6

Why is clarithromycin usually taken BD

Answer 6

It is more stable with less side effects

Question 7

Macrolides moa

Answer 7

inhibit protein synthesis

Question 8

Azithromycin chlamydia indication dose

Answer 8

1g and then 500mg for 2 days

Question 9

What serious disease can macrolides treat

Answer 9

Lymes disease

Azithromycin - 500mg OD for 17 days

Question 10

Labels for erythromycin

Answer 10

5 - take 2 hours before or after indigestion remedies

9 - space doses evenly

25 - do not chew or crush

Question 11

Dangers of increases dose of erythromycin

Answer 11

Hepatic toxicity
Ototoxicity
QT prolongation
Hypokalaemia

Question 12

When to avoid erythromycin in pregnant

Answer 12

If used to treat syphillis - does not reach baby do not useful to treat congenital problems

Question 13

Should clarithromycin be taken with food?

Answer 13

MR prep with food

Question 14

Patient advice with macrolides

Answer 14

Avoid alcohol

Question 15

How do erythromycin and clairthromycin increase concentration of drugs

Answer 15

Inhibitors so inc conc of statins and warfarin

Question 16

What do macrolifdes interact with to cause cardiac problems

Answer 16

w: hydroxychloroquine

Question 17

Why should maroclife not be given with warfarin or statins

Answer 17

Inc muscle pain or bleeding

Question 18

What drink to avoid with macrolides

Answer 18

Alcohol

Question 19

When to avoid clarithromycin

Answer 19

Pregnancy
Renal or hepatic impairment

Question 20

Max dose of azithromycin a day

Answer 20

1g

Question 21

Which macrolide has poor effect against h influenzae

Answer 21

Erythromycin

But clarithro and azithro are fine

Question 22

Can macrolides cause SJS

Answer 22

Yes

Question 24

How to take Clarithromycin MR

Answer 24

With or after food

Question 25

Labels for erythromycin

Answer 25

5,9,25

Question 26

Clarithromycin labels

Answer 26

9
13
21
25

Question 27

Which abx cause SJS

Answer 27

Co trimox
Glycopeptides
Clindamycin
Co trimoxazole
Trimethoprim

Question 28

When to avoid erythromycin

Answer 28

In syphillis as it does not treat congenital deformities in fetus

Also hepatotoxic so avoid

Question 29

What can cause ototoxicity in high doses

Answer 29

Erythromycin