Macrolides Flashcards
Which macrolide has long half life so used once daily
Azirhromycin
How to prevent nausea and vomiting with erythromycin
Give lower dose
What electrolyte imbalance do macrolides cause
Hypokalameia
Which macrolide safe in pregnancy and breastfeeding
Erythromycin
Which eradication is clarithromycin used in
H pylori
(With Amox and metronidazole)
Why is clarithromycin usually taken BD
It is more stable with less side effects
Macrolides moa
inhibit protein synthesis
Azithromycin chlamydia indication dose
1g and then 500mg for 2 days
What serious disease can macrolides treat
Lymes disease
Azithromycin - 500mg OD for 17 days
Labels for erythromycin
5 - take 2 hours before or after indigestion remedies
9 - space doses evenly
25 - do not chew or crush
Dangers of increases dose of erythromycin
Hepatic toxicity
Ototoxicity
QT prolongation
Hypokalaemia
When to avoid erythromycin in pregnant
If used to treat syphillis - does not reach baby do not useful to treat congenital problems
Should clarithromycin be taken with food?
MR prep with food
Patient advice with macrolides
Avoid alcohol
How do erythromycin and clairthromycin increase concentration of drugs
Inhibitors so inc conc of statins and warfarin
What do macrolifdes interact with to cause cardiac problems
w: hydroxychloroquine
Why should maroclife not be given with warfarin or statins
Inc muscle pain or bleeding
What drink to avoid with macrolides
Alcohol
When to avoid clarithromycin
Pregnancy
Renal or hepatic impairment
Max dose of azithromycin a day
1g
Which macrolide has poor effect against h influenzae
Erythromycin
But clarithro and azithro are fine
Can macrolides cause SJS
Yes
How to take Clarithromycin MR
With or after food
Labels for erythromycin
5,9,25
Clarithromycin labels
9
13
21
25
Which abx cause SJS
Co trimox
Glycopeptides
Clindamycin
Co trimoxazole
Trimethoprim
When to avoid erythromycin
In syphillis as it does not treat congenital deformities in fetus
Also hepatotoxic so avoid
What can cause ototoxicity in high doses
Erythromycin
