Linezolid

Question 1

Drug class of linezolid

Answer 1

Reversible non selective inhibitor of MAOI

Question 2

Linezolid use

Answer 2

Pneumonia
Gram positive infections

Question 3

MHRA warning linezolid

Answer 3

Optic neuropathy when used for more than 28 days

Blood disorder so FBC weekly especially if more than 10-14 days treatment

Question 4

When to monitor blood disorder in linezolid

Answer 4

Treatment more than 10-14 days

Have myelosupression

On drugs affecting blood count

Renal impairment

Question 5

Side effects of linezolid

Answer 5

Optic neuropathy
Blood disorder
Hypertensive crisis with SSRI, TCA, MAOI, opioids, buspirone

Question 6

How long to wait after stopping linezolid

Answer 6

2 weeks then start SSRI etc

Question 7

What food to avoid with linezolid

Answer 7

Tyramine rich
Soy, cheese, pickled veg, processed mes

Question 8

Max duration linezolid

Answer 8

28 days

Question 9

When is linezolid used in MRSA

Answer 9

when vancomycin not used or CI