Trimethoprim Flashcards
1
Q
How does trimethoprim work?
A
Inhibits dihydrofolate reductase and interrupts DNA and RNA synthesis
2
Q
What is trimethoprim effective against?
A
‘Coliforms’
- UTI
- MRSA
3
Q
What is trimethoprim contraindicated with and explain why?
A
- Methotrexate
- Both drugs block dihydrofolate reductase
- Causing severe bone marrow depression
4
Q
What is the main use of trimethoprim?
A
UTI
5
Q
Name two antibiotics that inhibit folate synthesis?
A
- Sulfonamides e.g. Sulphamethoxazole
2. Trimethoprim
6
Q
First line for UTI?
A
Trimethoprim
7
Q
Second line for UTI?
A
Nitrofunatoin
