Cephalosporin

Question 1

What group does Cefelexin belong to?

Answer 1

Cephalosporins but had beta lactam ring

Question 2

What does Cefelexin attack?

Answer 2

1. Gram + ( - Streptococci and Staph aureus)
2. Gram -
3. NOT ANAEROBES

Question 3

What is Cefelexin not effective against?

Answer 3

Anaerobes

Question 4

Side effects

Answer 4

• Can cause hypersensitivity/allergic reactions

Question 5

Clinical uses

Answer 5

1. UTI
2. Soft skin and tissue infection - used as an alternative to penicillin if allergy is mild
3. Intra abdominal infection

Question 6

Tx for cellulitis

Answer 6

First line - Flucoxicillin

Second line - Cephalexin

Question 7

Name two cephalosporins

Answer 7

1. Cefelexin

2. Ceftriaxone

Question 8

How do cephalosporins work?

Answer 8

Prevent cross-linking between peptidoglycans in bacterial cell wall (same as penicillins)

Question 9

Are cephalosporins bacteriostatic or bactericidal?

Answer 9

Bactericidal

Question 10

Are cephalosporins safe in pregnancy?

Answer 10

Yes

Question 11

What is a risk of cephalosporin use and why?

Answer 11

Development of C. difficile

Cephalosporins are a broad-spectrum antibiotic