Glycopeptides

Question 1

Main Glycopeptide antibiotic?

Answer 1

Vancomycin and Teicoplanin

Question 2

What route is vancomycin given?

Answer 2

IV as it is not absorbed by the gut

Question 3

Mechanism of action of Gycopeptide?

Answer 3

Acts on the cell wall

Question 4

What does vancomycin act against?

Answer 4

Gram + only

- Staph aureus/ Strep etc

Question 5

Name 3 main clinical uses of glycopeptides?

Answer 5

1. Treats skin and soft tissue infection in patients with severe penicillin allergy ( osteomyelitis/cellulitis)
2. Treats MRSA
3. C diff diarrhoea

Question 6

Name 2 major side effects of vancomycin?

Answer 6

1. Red man syndrome
2. Ototoxicity
3. Nephrotoxicity

Question 7

Which drug treats MRSA?

Answer 7

Teicoplanin

Question 8

Biggest cause of concern for Vancomycin?

Answer 8

1. Very narrow theraputic index thus easy toxicity

- can result in AKI