Aminoglycoside

Question 1

Name 2 aminoglycosides

Answer 1

1. Gentomycin

2. Steptomycin

Question 2

How do aminoglycosides work?

Answer 2

Inhibits binding of 30s sub unit in RNA

Question 3

What does Gentamycin act against?

Answer 3

Broad antibiotic - Gram - and Gram +

- Except Streptococci and enterococci

Question 4

Gentamycin is ineffective against which organisms?

Answer 4

1. Streptococci

2. Enterococci

Question 5

Side effects (2)

Answer 5

1. Mainly excreted by kidney so kidney impairment can cause toxicity and accumulation
2. Nephro and oto toxic

Question 6

Clinical uses of aminoglycosides

Answer 6

Often giving with beta lactams

• Gram negative sepsis incl psuedomonas
• Pyelonephritis
• Bacterial endocarditis